Study of Itching Pruritus in Adults With Drug-Induced Liver Injury DILI to Understand Its Course and Impact

What this Trial Is About

This research focuses on idiosyncratic drug-induced liver injury DILI, an unpredictable liver reaction to medications taken at normal doses. DILI is a significant cause of itching pruritus in adults, second only to biliary obstruction, especially in cholestatic or mixed types where bile flow is impaired. The study aims to better understand how often itching occurs in DILI and its effects on patients quality of life, establishing a network of centers for future treatment trials. Participants diagnosed with suspected acute DILI based on specific liver enzyme levels will be observed. The study monitors the incidence, duration, and severity of itching in these patients over several years, along with genetic factors linked to itching. The study does not involve experimental treatments but collects detailed data to inform future therapeutic approaches. During the study, participants will undergo clinical evaluations including liver function tests within 36 hours of enrollment. Patient-reported health status and quality of life will be assessed over a follow-up period of up to four years. Researchers aim to gather comprehensive information on the natural history of itching in DILI, including genetic influences and symptom progression, to support the development of new treatments and improve patient care.

Drug-induced Liver Injury: Itching Study