Actively Recruiting
Drug-induced Liver Injury: Itching Study
Led by University of Nottingham · Updated on 2026-04-30
50
Participants Needed
1
Research Sites
148 weeks
Total Duration
On this page
Sponsors
U
University of Nottingham
Lead Sponsor
I
Ipsen
Collaborating Sponsor
AI-Summary
What this Trial Is About
Idiosyncratic drug-induced liver injury (DILI) is an unpredictable adverse hepatic reaction to a medication used in its therapeutic dose. DILI is the second most common cause of itching in adult Hepatology after biliary obstruction. In particular cholestatic or mixed pattern types of DILI (in which bile flow from the liver is impaired) are associated with long-lasting effects as well as reduced quality of life. There is therefore an urgent need to determine the incidence and natural history of itching in DILI and establish a network of centres that will form a basis for a clinical trial to investigate a novel intervention to treat these.
CONDITIONS
Official Title
Drug-induced Liver Injury: Itching Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 or older and able to give informed written consent
- Exposure to a potential causal agent and diagnosed with suspected acute DILI defined by one of the following at enrollment: alanine transaminase (ALT) 5 times upper limit of normal (ULN) or alkaline phosphatase 2 times ULN or ALT 3 times ULN plus total bilirubin over 2 times ULN
- Clinical test results within 36 hours of enrollment visit acceptable
You will not qualify if you...
- Patients with eczema or urticaria causing itching
- Patients with diagnosed blood-borne viral hepatitis infection (Hepatitis B, C, or E)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Nottingham University Hospitals NHS Trust
Nottingham, United Kingdom
Actively Recruiting
Research Team
E
Elinor Study Coordinator
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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