Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Apnea

What this Trial Is About

Researchers are evaluating drug-induced sleep endoscopy (DISE) to assess the upper airway in adults with obstructive sleep apnea (OSA) who are considering surgery. This interventional study, sponsored by the University of California, Los Angeles, explores the reliability of DISE and its comparison with other evaluation methods like lateral cephalogram X-rays and the Mueller maneuver. The study also examines how DISE findings relate to surgical outcomes, including in patients who did not respond to prior sleep apnea surgery. Participants receive an intravenous infusion of propofol sedation, adjusted to induce sleep while maintaining responsiveness to verbal stimuli. This sedation allows detailed examination of the upper airway during sleep. The study focuses on patients considering surgical treatment for OSA, with no blinding or placebo control. The research spans preoperative and postoperative assessments to correlate DISE results with physical exams, sleep studies, and imaging. During the study, participants undergo DISE under propofol sedation and evaluations including physical examinations, polysomnograms, awake Mueller maneuvers, and lateral cephalometry. Researchers monitor associations between these assessments and surgical outcomes. The study involves ongoing research activities with follow-up to analyze these relationships. Participants remain in the study as needed to complete these assessments and provide surgical outcome data, with no specified maximum age limit.

Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Apnea