Actively Recruiting
Drug Response Profiling (DRP) Registry Zurich for Hematological Malignancies
Led by University Children's Hospital, Zurich · Updated on 2024-08-15
1000
Participants Needed
1
Research Sites
521 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a prospective, non-randomized feasibility study of drug response profiling (DRP) in pediatric blood cancers. Primary cancer cells are isolated from patients and screened ex vivo at single-cell resolution using automated fluorescence microscopy. Drug sensitivity fingerprints are integrated with genetic annotations to inform the treating physician about personalized treatment options. The study aims to determine the practicability of real-time drug response profiling and its actionability in identifying patient-specific cancer dependencies in refractory disease settings.
CONDITIONS
Official Title
Drug Response Profiling (DRP) Registry Zurich for Hematological Malignancies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pediatric and adult patients below the age of 40 years
- Diagnosis of hematological malignancy (primary, relapsed or refractory) including leukemia, myeloma or lymphoma
- Tumor material collected as part of routine diagnostics and willingness to donate tumor material for translational research
- Patient and/or guardian has signed the informed consent of the DRP registry or of a clinical trial which includes DRP as add-on research.
You will not qualify if you...
- Missing informed consent for the registry or of a clinical trial which includes DRP as add-on research
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Children's Hospital Zurich
Zurich, Canton of Zurich, Switzerland, 8032
Actively Recruiting
Research Team
J
Jean-Pierre Bourquin, MD, PhD
CONTACT
F
Fabio Steffen, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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