Actively Recruiting
Drug Response Testing and Repurposing Using Glioblastoma Organoid
Led by Chungnam National University Hospital · Updated on 2025-01-20
150
Participants Needed
1
Research Sites
484 weeks
Total Duration
On this page
Sponsors
C
Chungnam National University Hospital
Lead Sponsor
K
Korea Advanced Institute of Science and Technology
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this observational study, based on a prospectively collected cohort, is to evaluate the prognostic value of patient-derived organoids in predicting responses to conventional and repurposing drugs, including temozolomide, in patients with primary or recurrent glioblastoma. The primary question is whether the patient's response to temozolomide is recapitulated in their corresponding patient-derived glioblastoma organoid (GBO). Patient drug responses are evaluated using survival data, while GBO drug responses are assessed through a drug-response testing platform utilizing cell viability assays. Additionally, this platform is used to explore the potential application of various chemotherapeutic agents.
CONDITIONS
Official Title
Drug Response Testing and Repurposing Using Glioblastoma Organoid
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Primary or recurrent glioblastoma
- Patients treated with standard treatment including surgery and temozolomide based chemoradiation therapy
- Sufficient tumor sample is available for organoid culture
You will not qualify if you...
- Patients who have not undergone concurrent chemoradiation therapy following surgery
- Failure to obtain MRI scan after concurrent chemoradiation therapy
- Patient refusal
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Chungnam National University Hospital
Daejeon, Chungcheongnam-do, South Korea, 35015
Actively Recruiting
Research Team
K
Kyung Hwan Kim, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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