Diaphragmatic Tissue Doppler Imaging During a Spontaneous Breathing Trial to Predict Extubation Failure in Preterm Infants

What this Trial Is About

Researchers are evaluating the use of diaphragmatic tissue Doppler imaging (dTDI) to study diaphragmatic excursion velocity in premature infants during a spontaneous breathing trial (SBT). The goal is to understand how diaphragm movement relates to the success or failure of weaning from mechanical ventilation. This observational study focuses on preterm infants supported by invasive mechanical ventilation for at least 48 hours and aims to predict extubation failure, which is a critical issue linked to diaphragmatic dysfunction. During the study, dTDI is performed at the end of the SBT to assess the diaphragm's excursion, velocity, and acceleration in both inspiration and expiration phases. Patients are grouped based on their success or failure during weaning: those who require re-intubation within 48 hours after passing the SBT are considered to have failed weaning, while those who do not require invasive ventilation within 48 hours after extubation are considered successful. The main focus is on measuring changes in diaphragmatic displacement velocity over an average of 20 minutes. Participants are monitored for various outcomes including diaphragmatic acceleration and deceleration, gas exchange parameters like arterial carbon dioxide tension, pH, and oxygen tension, as well as respiratory severity scores. The study closely observes the number of patients experiencing weaning failure within 48 hours. Data collection occurs during the SBT and throughout the 48-hour post-extubation period, with parental consent required for participation. The study is led by Wang Jianhui and is ongoing until December 25, 2024.

dTDI During a SBT to Predict Extubation Failure in Preterm Infants