Actively Recruiting
dTMS for Subjective Cognitive Decline
Led by Rotman Research Institute at Baycrest · Updated on 2025-10-27
30
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
R
Rotman Research Institute at Baycrest
Lead Sponsor
B
Brainsway
Collaborating Sponsor
AI-Summary
What this Trial Is About
Deep transcranial magnetic stimulation (dTMS) is a brain stimulation technique that involves generating a brief magnetic field in a coil that is placed on the scalp. The magnetic field passes through the skull and induces a weak electrical current in the brain that briefly activates neural circuits at the stimulation site. The Brainsway dTMS H7-Coil is able to target an area of the brain that has been shown in studies to be linked to greater resilience to cognitive decline. In this study, the investigators will combine dTMS with cognitive training in older adults with subjective cognitive decline (SCD) and examine the effect of this treatment on memory, other cognitive abilities, and mood. In addition, the investigators will examine the combined effects of dTMS and cognitive training on brain activity as measured using electroencephalography (EEG). Approximately 30 older adults from ages 55 to 70 with SCD and a positive family history of Alzheimer's disease will be enrolled in this study.
CONDITIONS
Official Title
dTMS for Subjective Cognitive Decline
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a first-degree relative with probable or confirmed late onset sporadic Alzheimer's disease
- Experience subjective memory decline and are concerned about memory changes
- Score 26 or higher on the Montreal Cognitive Assessment (MoCA)
- Are willing to provide informed consent
- Are able to follow the treatment schedule
- Are stable on medications for at least 2 months and do not plan medication changes during the study
- Pass a safety screening questionnaire for transcranial magnetic stimulation (TMS)
- Have an informant or study partner able to complete questionnaires about the participant
You will not qualify if you...
- Have a metal plate in the head except in the mouth (e.g., ear implant, brain stimulators, aneurysm clips)
- Have known or history of increased brain pressure increasing seizure risk
- Have a cardiac pacemaker
- Have an implanted medication pump
- Have a central venous line
- Have a significant heart condition
- Have current depression or history of psychotic disorders, bipolar disorder, eating disorder, obsessive-compulsive disorder, post-traumatic stress disorder, or dementia other than Alzheimer's disease
- Have substance abuse history in the last 6 months
- Have a history of stroke or other brain lesions
- Have personal or family history of epilepsy
- Are pregnant or breastfeeding
- Have abnormal MRI brain findings
- Have significant hearing loss requiring hearing aids
- Have untreated hypo- or hyper-thyroidism
- Have contraindications to TMS
- Have unstable medical conditions
- Regularly use benzodiazepines or other hypnotics within 2 weeks before randomization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rotman Research Institute at Baycrest
Toronto, Ontario, Canada, M6A 2E1
Actively Recruiting
Research Team
A
Amanda Rahmadian
CONTACT
L
Linda Mah
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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