Actively Recruiting
Dual-energy CT vs. MRI in the Evaluation of Squamous Cell Carcinomas of the Oral Cavity and Oropharynx
Led by University Hospital, Strasbourg, France · Updated on 2026-01-15
30
Participants Needed
1
Research Sites
1 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the use of 40keV dual-energy CT scans compared to MRI for assessing squamous cell carcinomas of the oral cavity and oropharynx. The study aims to determine if the dual-energy CT can provide a diagnosis that is not inferior to MRI, potentially speeding up pre-treatment assessments and reducing delays in starting treatment. This evaluation is important because current protocols require both CT and MRI scans, which can slow down the treatment process and limit MRI availability. Participants will undergo both contrast-enhanced cervicofacial MRI and contrast-enhanced cervicofacial dual-energy CT scans using the BOLT maneuver. The study will compare the agreement between these imaging methods in determining the T stage of the tumor according to the TNM classification. This observational study does not involve additional treatments but focuses on comparing diagnostic imaging techniques. During the study, participants will receive clinical examinations including nasofibroscopy by specialized ENT surgeons, as well as the required imaging scans. Researchers will monitor and measure the overall agreement between the CT and MRI results for tumor staging over a period of up to 12 months. The study intends to improve diagnostic efficiency and reduce patient delays without compromising assessment quality.
CONDITIONS
Brief Title
Dual-energy CT vs. MRI in the Evaluation of Squamous Cell Carcinomas of the Oral Cavity and Oropharynx
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient (18 years or older)
- Diagnosed with oral or oropharyngeal squamous cell carcinoma confirmed by biopsy
- Have undergone a clinical examination with nasofibroscopy by an ENT surgeon specializing in cancer surgery
- Have had a contrast-enhanced cervicofacial MRI
- Have had a contrast-enhanced cervicofacial dual-energy CT with BOLT maneuver
You will not qualify if you...
- Presence of a lesion other than oral or oropharyngeal squamous cell carcinoma
- Lesion located on the lip (labial location)
- Contraindication to performing one or both imaging examinations (MRI or CT)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo both contrast-enhanced cervicofacial MRI and dual-energy CT scans to evaluate squamous cell carcinomas of the oral cavity and oropharynx.
1 visit (in-person)
Duration - Up to 12 months
Participants are observed for up to 12 months to assess agreement on the cancer staging based on imaging results.
Follow-up visits as scheduled by the clinical team
Trial Site Locations
Total: 1 location
1
Service d'ORL et de Chirurgie Cervico-faciale - CHU de Strasbourg - France
Strasbourg, France, 67091
Actively Recruiting
Research Team
P
Philippe Schultz, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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