Actively Recruiting
Dual Modulation of Sigma-1 and NMDA Receptors in the Treatment of Schizophrenia
Led by China Medical University Hospital · Updated on 2026-03-24
90
Participants Needed
1
Research Sites
231 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
sigma-1 receptor (S1R) agonistic property have been tested in clinical trials for the treatment of schizophrenia. In addition, previous studies found that some NMDA receptor (NMDAR)-enhancing agents were able to improve clinical symptoms of patients with chronic schizophrenia. Whether combined treatment of an S1R agonist and an NMDA-enhancing agent can be better than an S1R agonist alone deserves study.
CONDITIONS
Official Title
Dual Modulation of Sigma-1 and NMDA Receptors in the Treatment of Schizophrenia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a DSM-5 diagnosis of schizophrenia
- Resistant to adequate treatments with at least two antipsychotics (excluding clozapine)
- Remain symptomatic without significant fluctuations, with unchanged antipsychotic doses for at least 3 months
- PANSS total score greater than 70
- Hamilton Depression Rating Scale-17 items (HAMD) score less than 7
- Physically healthy with clinically insignificant laboratory assessments
- Have sufficient education to communicate and complete study assessments
- Agree to participate and provide informed consent
You will not qualify if you...
- Diagnosis of intellectual disability or substance use disorder (including alcohol) according to DSM-5
- History of epilepsy, head trauma, central nervous system diseases, or mental disorders other than schizophrenia
- Pregnancy or lactation
- Inability to follow the study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Psychiatry, China Medical University Hospital
Taichung, Taiwan
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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