Actively Recruiting
DUET Versus Standard Interface for Hypercapnic COPD Patients
Led by Larissa University Hospital · Updated on 2025-09-10
50
Participants Needed
2
Research Sites
123 weeks
Total Duration
On this page
Sponsors
L
Larissa University Hospital
Lead Sponsor
S
Sotiria General Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare the new asymmetric nasal high flow interface with the conventional high flow nasal cannula in patients with COPD exacerbation. The main questions the study aims to answer are: • Does the use of the asymmetric interface lead to: 1. A greater decrease in the patients' carbon dioxide 2. A greater decrease in respiratory rate and less dyspnea 3. Less need for advanced oxygen therapy measures 4. Same tolerance and comfort 5. Lower heart rate and blood pressure Participants will be asked to: Wear the asymmetric and conventional cannulas for 3 hours each with a 30 minute gap in-between. Arterial blood samples and various clinical parameters will be collected throughout the study period. Researchers will compare the effect of asymmetric versus conventional cannulas to answer the aforementioned questions.
CONDITIONS
Official Title
DUET Versus Standard Interface for Hypercapnic COPD Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Acute exacerbation of COPD causing worsening respiratory symptoms and medication change
- Mild to moderate acute hypercapnic respiratory failure with pH between 7.25 and 7.35 and arterial CO2 tension above 45 mmHg
You will not qualify if you...
- Acute on chronic hypercapnic respiratory failure
- Severe facial deformity, facial burns, or fixed upper airway obstruction
- Conditions requiring imminent intubation or invasive ventilation such as respiratory or cardiac arrest
- Diminished consciousness (Glasgow coma score below 8)
- Psychomotor agitation not controlled by sedation
- Massive aspiration
- Inability to clear respiratory secretions
- Severe hemodynamic instability unresponsive to fluids and drugs
- Severe ventricular or supraventricular arrhythmias
- Life-threatening low blood oxygen levels
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Sotiria General Hospital
Athens, Greece, 11527
Actively Recruiting
2
University Hospital of Larissa
Larissa, Greece, 41110
Actively Recruiting
Research Team
I
Ioannis Pantazopoulos, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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