Actively Recruiting

Phase 4
Age: 18Years +
All Genders
NCT06807866

Duloxetine for Perioperative Pain in Hip Arthroplasty: A RCT

Led by University of Miami · Updated on 2026-03-18

64

Participants Needed

1

Research Sites

91 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The primary objective of this study is to compare total narcotic intake standardized via milligram morphine equivalents between duloxetine and placebo cohorts after a total hip arthroplasty.

CONDITIONS

Official Title

Duloxetine for Perioperative Pain in Hip Arthroplasty: A RCT

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients over 18 years of age
  • Patients undergoing primary total hip arthroplasty
  • Ambulatory patient prior to fracture
  • Subjects must be capable of providing informed consent
  • English or Spanish speaking
Not Eligible

You will not qualify if you...

  • Previous hemiarthroplasty or total hip arthroplasty on the same hip
  • History of Complex Regional Pain Syndrome in the same leg
  • History of demyelinating disorder or neurologic deficit affecting pain tolerance or sensation
  • Acute or chronic hip infection in the same leg
  • Pregnant or breastfeeding
  • Open fracture
  • Polytrauma
  • Intravenous drug or drug users within 6 months before surgery
  • Liver failure diagnosed clinically or with abnormal blood clotting tests
  • Use of selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, monoamine oxidase inhibitors, or tricyclic antidepressants
  • Severe kidney problems such as a glomerular filtration rate less than 30
  • Moderate to severe depression diagnosed by a clinician
  • Taking cytochrome P450 1A2 or 1A6 inhibitors for the duration of five half-lives
  • History of uncontrolled narrow angle glaucoma

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University of Miami

Miami, Florida, United States, 33136

Actively Recruiting

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Research Team

V

Victor Hernandez, MD

CONTACT

N

Natalia Cruz, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

2

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