Study of Dumping Syndrome in Babies with Esophageal Atresia Using Continuous Glucose and Heart Monitoring and Gastric Tests

What this Trial Is About

Dumping syndrome DS often occurs in infants with oesophageal atresia, affecting about 29% and causing dangerous low blood sugar levels after meals. This condition is hard to diagnose because symptoms appear inconsistently after eating. Currently, only symptom relief treatments exist. The study aims to better understand the causes of DS to improve treatment and prevent complications in infants born with oesophageal atresia. The study involves infants aged 2 to 3 months who were born with oesophageal atresia type C. Participants will undergo continuous blood sugar monitoring using a Glycemic Holter, continuous heart monitoring with a Holter ECG, and a gastric emptying scintigraphy test that tracks how quickly the stomach empties after feeding. The gastric emptying test involves drinking a milk bottle labeled with a safe radioactive marker and having a camera measure remaining radioactivity every 30 minutes for 4 hours. During the study, infants will be observed for abnormal blood sugar levels linked to nerve activity and stomach emptying over 48 hours. Researchers will also check if dumping syndrome persists at 6 months and assess how well infants tolerate the glucose monitoring. The total study period covers monitoring and follow-up assessments to better understand DS mechanisms and its effects on these infants.

Dumping Syndrome and Esophageal Atresia