Actively Recruiting
Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study
Led by Monash University · Updated on 2026-03-25
9180
Participants Needed
27
Research Sites
277 weeks
Total Duration
On this page
Sponsors
M
Monash University
Lead Sponsor
A
ANZCA CTN
Collaborating Sponsor
AI-Summary
What this Trial Is About
This multicentre, adaptive, pragmatic, double-blind, three-arm, placebo-controlled, randomised, non-inferiority clinical trial will compare the incidence of surgical site infection and other healthcare associated infections, health economic and microbiological impact after intraoperative only (Arm A), to 24 hours (Arm B) and, to 48 hours (Arm C) of IV cefazolin and placebo postoperative surgical antimicrobial prophylaxis in patients undergoing cardiac surgery
CONDITIONS
Official Title
Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients undergoing cardiac surgery involving a median sternotomy
You will not qualify if you...
- Age under 18 years
- American Society of Anesthesiology (ASA) classification 5
- Glomerular filtration rate (GFR) less than 40 mL/min/1.73m2 or need for continuous renal replacement therapy, haemodialysis, or peritoneal dialysis
- Surgery for suspected or confirmed endocarditis or deep sternal wound infection
- Known allergy to cefazolin
- Documented methicillin-resistant Staphylococcus aureus (MRSA) colonisation or infection in the 12 months before surgery
- Cardiac transplantation
- Procedures involving insertion of a ventricular assist device or mechanical circulatory support device
- Surgeries not involving a median sternotomy
- Patients previously enrolled and randomized in the CALIPSO trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 27 locations
1
UT Southwestern Medical Centre
Dallas, Texas, United States, 75390
Not Yet Recruiting
2
Westmead Hospital
Sydney, New South Wales, Australia, 2145
Actively Recruiting
3
St George Hospital
Sydney, New South Wales, Australia, 2217
Active, Not Recruiting
4
The Prince Charles Hospital
Brisbane, Queensland, Australia, 4032
Actively Recruiting
5
Princess Alexandra Hospital
Brisbane, Queensland, Australia, 4102
Actively Recruiting
6
St Andrew's War Memorial Hospital
Brisbane, Queensland, Australia
Active, Not Recruiting
7
Royal Adelaide Hospital
Adelaide, South Australia, Australia, 5000
Actively Recruiting
8
Flinders Medical Centre
Adelaide, South Australia, Australia, 5042
Actively Recruiting
9
Flinders Private
Adelaide, South Australia, Australia, 5042
Actively Recruiting
10
Royal Hobart Hospital
Hobart, Tasmania, Australia, 7000
Actively Recruiting
11
The Alfred Hospital
Melbourne, Victoria, Australia, 3004
Actively Recruiting
12
The Royal Melbourne Hospital
Melbourne, Victoria, Australia, 3050
Actively Recruiting
13
Austin Health
Melbourne, Victoria, Australia, 3084
Actively Recruiting
14
Epworth HealthCare
Melbourne, Victoria, Australia, 3121
Actively Recruiting
15
Cabrini Health
Melbourne, Victoria, Australia, 3144
Actively Recruiting
16
Victorian Heart Hospital
Melbourne, Victoria, Australia, 3168
Actively Recruiting
17
Sir Charles Gairdner
Nedlands, Western Australia, Australia
Not Yet Recruiting
18
St John of God Subiaco Hospital
Perth, Western Australia, Australia, 6008
Actively Recruiting
19
Fiona Stanley Hospital
Perth, Western Australia, Australia
Actively Recruiting
20
St Vincent's Hospital
Melbourne, Australia
Actively Recruiting
21
Halifax Infirmary
Halifax, Nova Scotia, Canada
Actively Recruiting
22
IJN
Kuala Lumpur, Malaysia
Actively Recruiting
23
UMMC
Kuala Lumpur, Malaysia
Not Yet Recruiting
24
Christchurch Hospital
Christchurch, New Zealand
Actively Recruiting
25
Waikato Hospital
Hamilton, New Zealand, 3204
Actively Recruiting
26
Wakefield Hospital
Wellington, New Zealand
Not Yet Recruiting
27
Wellington Hospital
Wellington, New Zealand
Actively Recruiting
Research Team
P
Paige Druce, MSc(Epi)
CONTACT
S
Sarah Astbury
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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