Actively Recruiting
Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes
Led by Medical University of Graz · Updated on 2026-05-14
76
Participants Needed
1
Research Sites
145 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Respiratory distress syndrome (RDS) is common in very preterm infants due to surfactant deficiency. Surfactant replacement therapy is lifesaving, and current guidelines recommend the less invasive surfactant administration (LISA) technique. However, the optimal duration of surfactant instillation during LISA has never been systematically evaluated. Rapid instillation may provoke transient hypoxia and bradycardia, while slower administration might improve physiological stability and cerebral oxygenation. This randomised controlled trial investigates whether the duration of surfactant administration (1 minute versus 5 minutes) affects cerebral and systemic oxygen stability in extremely preterm neonates (\< 28 weeks).
CONDITIONS
Official Title
Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Preterm neonate less than 28 weeks gestational age (up to 27 weeks and 6 days)
- Indication for surfactant administration via the LISA method
- Postnatal age less than 72 hours
You will not qualify if you...
- Receiving invasive ventilation or indication for INSURE procedure
- Severe lung or heart malformations affecting oxygenation or congenital brain malformation
- Preexisting diagnosis of brain hemorrhage greater than grade 2 or periventricular hemorrhagic infarction
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Medical University of Graz, Division of Neonatology, Department of Pediatrics and Adolescent Medicine
Graz, Austria, 8036
Actively Recruiting
Research Team
C
Christina H. Wolfsberger, Priv.Doz. DDr.
CONTACT
G
Gerhard Pichler, Univ.Prof. PD. Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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