Actively Recruiting
Dynamic Compliance-Guided Ventilation in Lumbar Surgery
Led by Ankara City Hospital Bilkent · Updated on 2026-01-27
71
Participants Needed
1
Research Sites
18 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Postoperative pulmonary complications are a frequent cause of morbidity following lumbar stabilization surgery. Conventional ventilation strategies may not adequately reflect intraoperative changes in respiratory mechanics, potentially leading to impaired postoperative pulmonary function. Dynamic compliance-guided ventilation provides a real-time, individualized approach by adjusting ventilatory parameters according to lung compliance. This prospective randomized controlled study aims to evaluate the effects of dynamic compliance-guided ventilation compared with standard ventilation strategies on postoperative pulmonary function in patients undergoing lumbar stabilization surgery. Eligible patients will be randomly assigned to either the compliance-guided group or the conventional ventilation group. In this study, the investigators aim to prospectively compare ventilation with the dynamic compliance (Cdyn) approach-one of the lung-protective ventilation strategies-with conventional ventilation methods in patients undergoing surgery in the prone position. The primary outcome will be evaluated using a modified lung ultrasound scoring system based on the most severely affected regions of aeration loss. Secondary objectives include the assessment of intraoperative hemodynamics, respiratory mechanics, and the effects on postoperative pulmonary function.
CONDITIONS
Official Title
Dynamic Compliance-Guided Ventilation in Lumbar Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who will undergo lumbar stabilization in the prone position
You will not qualify if you...
- Patients with ASA classification IV or higher
- Patients with obesity (BMI >30) or cachexia (BMI <18)
- Allergy to standard medications used during general anesthesia
- Contraindications to PEEP such as high intracranial pressure, bronchopleural fistula, hypovolemic shock, or right heart failure
- Previous lung surgery of any kind
- Known serious heart disease defined as New York Heart Association class III or higher
- Patients with severe asthma and COPD
- Acute myocardial infarction within the last 12 months before surgery
- Neuromuscular disease
AI-Screening
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Trial Site Locations
Total: 1 location
1
Ankara Bilkent City Hospital
Ankara, Turkey (Türkiye), 06800
Actively Recruiting
Research Team
B
Burak Nalbant
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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