Actively Recruiting
Dynamics in Bone Turnover Markers During and After Short-term Glucocorticoid Treatment in Patients With an Inflammatory Joint Disease
Led by Diakonhjemmet Hospital · Updated on 2025-08-24
160
Participants Needed
2
Research Sites
204 weeks
Total Duration
On this page
Sponsors
D
Diakonhjemmet Hospital
Lead Sponsor
V
Vestre Viken Hospital Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
Bone turnover markers (BTMs) are recommended as an important tool in follow-up of osteoporosis treatment. However, there is a lack of knowledge in the reliability of BTMs during and after glucocorticoid treatment. Glucocorticoids suppresses BTMs during treatment with at least 30% and, moreover, glucocorticoids increase the risk of fractures. Patients with an inflammatory joint disease are at increased risk of osteoporosis, and disease flares are often treated with glucocorticoids, which in turn can lead to loss in reliability of the BTMs in patients who also are on osteoporosis treatment. There is a need of more knowledge on BTM changes during and after glucocorticoid treatment for optimized patientcare, reduced risk of side effects and reduced health economic costs.
CONDITIONS
Official Title
Dynamics in Bone Turnover Markers During and After Short-term Glucocorticoid Treatment in Patients With an Inflammatory Joint Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of inflammatory rheumatic joint disease
- Indication for starting disease modifying treatment with or without glucocorticoids OR stable DMARD treatment with parenteral glucocorticoid injection
- Age between 25 and 90 years
You will not qualify if you...
- Known osteoporosis or treatment for osteoporosis
- Women in transitory phase
- Oestrogen treatment
- Any fracture within the last year
- Chronic glucocorticoid treatment
- Glucocorticoid treatment within the last year prior to inclusion
- Active cancer
- Kidney failure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Vestre Viken HF, Drammen
Drammen, Norway, 3024
Actively Recruiting
2
Diakonhjemmet hospital
Oslo, Norway, 0319
Actively Recruiting
Research Team
B
Birgitte Nellemann Nellemann, MD PHD
CONTACT
T
Tove T Borgen, MD PHD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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