Actively Recruiting
Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma
Led by University Hospital, Rouen · Updated on 2026-02-17
100
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Nature of potential dysbiosis, interrelation of the different microbiomes of the respiratory tract, and potential role of the immune system in the pathogenesis of severe asthma in infants, and its evolution under treatment. Exploring and understanding these data is to improve patient care and discover new therapeutic targets. The aim is to open up prospects for therapeutic studies, such as the use of azithromycin as an immunomodulator in infant asthma, the results of which are discordant.
CONDITIONS
Official Title
Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Infants less than 24 months old
- Follow-up by a pneumo-pediatrician for severe asthma in infants
- Requiring etiological investigations and assessment of severity in day hospitalization, including bronchial fibroscopy (HAS 2009)
- Parent informed of the research and having signed consent
You will not qualify if you...
- Prematurity less than 32 weeks of gestation
- Congenital heart disease with significant left to right shunt
- Chronic respiratory disease other than infant asthma (cystic fibrosis, bronchiolitis obliterans)
- Antibiotic therapy in progress or administered the seven days preceding the date of inclusion (day hospitalization)
- Refusal of bronchial fibroscopy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rouen University Hospital
Rouen, France
Actively Recruiting
Research Team
D
David Mallet
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here