Actively Recruiting
Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2026-05-06
240
Participants Needed
7
Research Sites
153 weeks
Total Duration
On this page
Sponsors
U
Universitaire Ziekenhuizen KU Leuven
Lead Sponsor
U
University Hospital, Geneva
Collaborating Sponsor
AI-Summary
What this Trial Is About
Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction (OD) in patients with well-documented olfactory function. The investigators plan to collect olfactory cleft biopsies and cytobrushes in COVID-19 patients and controls.
CONDITIONS
Official Title
Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For olfactory dysfunction group: Presence of clear smell problems such as parosmia or a TDI-score of 24 or less
- For olfactory dysfunction group: Subjective smell impairment with a visual analogue score of 5 or higher out of 10
- For control group: No smell problems with a TDI-score greater than 30.5
- Adults aged 18 to 70 years
You will not qualify if you...
- Nasal mucosal diseases that might affect smell or interfere with study tests
- Use of anticoagulation therapy
- Allergy to local anesthetics
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Cliniques Universitaires Saint-Luc
Brussels, Brussels Capital, Belgium, 1000
Actively Recruiting
2
UZ/KU Leuven
Leuven, Vlaams-Brabant, Belgium, 3000
Actively Recruiting
3
AZ Sint-Jan Brugge
Bruges, West-Vlaanderen, Belgium, 8000
Actively Recruiting
4
University Hospital Carl Gustav Carus
Dresden, Dresden, Germany, 01307
Actively Recruiting
5
Max Planck Research Unit for Neurogenetics
Frankfurt am Main, Frankfurt, Germany, 60438
Active, Not Recruiting
6
Hôpitaux Universitaires de Genève
Geneva, Canton of Geneva, Switzerland, 1211
Actively Recruiting
7
University of Zurich and University Hospital Zurich
Zurich, Canton of Zurich, Switzerland, 8091
Actively Recruiting
Research Team
L
Laura van Gerven
CONTACT
S
Sabrina Bischoff
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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