Actively Recruiting
DZD8586 in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
Led by Dizal Pharmaceuticals · Updated on 2025-08-11
230
Participants Needed
5
Research Sites
232 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will treat patients with B-NHL who have relapsed, progressed, or were intolerant to systemic therapy progressed following prior therapy. This study will help to understand what type of side effects may occur with the drug treatment. It will also measure the levels of drug in the body and assess its anti-cancer activity as monotherapy.
CONDITIONS
Official Title
DZD8586 in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female participants who have provided ICF with age ≥ 18 yrs
- ECOG performance 0-2, no deterioration in the past 2 weeks
- Participants with relapsed or refractory B-NHL must have cytologically or histologically confirmed B-cell lymphoma
- Adequate bone marrow reserve and organ system functions
- Participants willing to comply with contraceptive restrictions
You will not qualify if you...
- Any unresolved > Grade 1 adverse event at the time of starting study treatment with the exception of alopecia.
- Prior history of allogeneic hematopoietic stem cell transplantation
- Stem cell transplantation, cell therapy, or gene therapy within 90 days. Approved small molecule therapy within 5 half-lives, investigational small molecule therapy within 14 days. Monoclonal antibodies and antibody-drug conjugates within 28 days Radiation therapy within 1 weeks
- Live attenuated vaccines or viral vector vaccines within 4 weeks. Major surgery or significant traumatic injury within 4 weeks. History of stroke or intracranial hemorrhage within 6 months
- Participants with non-CNSL presence of CNS or intraocular lymphoma lesions.
- CNSL participants with systemic presence of lymphoma, unable to complete lumbar puncture, under systemic corticosteroids at a dose > 8 mg/day (dexamethasone equivalent dose) within 14 days or requiring immunosuppressive or biologic therapy."
- Participants with infectious disease:
- Clinically significant cardiac disorders or abnormalities
- Another malignancy within 5 years prior to enrollment with the exception of adequately treated in-situ carcinoma of the cervix, uterus, basal or squamous cell carcinoma or non-melanomatous skin cancer.
- Refractory nausea and vomiting if not controlled by supportive therapy, chronic gastrointestinal diseases, inability to swallow the formulated product or previous significant bowel resection that would preclude adequate absorption
- Women who are breast feeding
- Psychological, familial, sociological, or geographical conditions that do not permit compliance with the protocol
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 5 locations
1
Research site
New York, New York, United States, 10065
Not Yet Recruiting
2
Research site
Albury, New South Wales, Australia
Actively Recruiting
3
Research site
Ballarat, Victoria, Australia
Not Yet Recruiting
4
Research site
Melbourne, Victoria, Australia
Actively Recruiting
5
Research site
Perth, Western Australia, Australia
Actively Recruiting
Research Team
Z
Ziyi Liu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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