Comparing E-cigarettes and Nicotine Replacement Therapy for Harm Reduction in Adults With Serious Mental Illness Who Smoke

What this Trial Is About

Researchers are evaluating harm reduction strategies for adult smokers diagnosed with Serious Mental Illness SMI who use combustible cigarettes. The study compares the effects of e-cigarettes EC and nicotine replacement therapy NRT combined with harm-reduction counseling and Ecological Momentary Intervention EMI text messaging. The goal is to assess which approach better helps reduce cigarette smoking in this population. Participants are randomly assigned to one of two groups one receives e-cigarettes along with nicotine patches and lozenges, while the other uses only nicotine replacement therapy products such as patches and lozenges. Both groups receive motivational counseling via telehealth sessions over an 8-week intervention period. Throughout this time, personalized text messages support behavior change as part of the EMI. During the study, participants are monitored for smoking reduction by checking the percentage who stop smoking cigarettes entirely by weeks 4 and 8, with additional follow-up at week 12. Assessments include self-reported changes in cigarette use and questionnaires measuring respiratory and mental health symptoms. The study tracks adherence to treatments and counseling, with data collected through electronic messages and regular evaluations. Participation continues until the last follow-up at 12 weeks.

E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness