Study of Early Comprehensive Exercise and Breathing Muscle Training to Improve Quality of Life in Adults with Acute Decompensated Heart Failure

What this Trial Is About

Researchers are studying patients with Acute Decompensated Heart Failure ADHF to evaluate the effects of early comprehensive rehabilitation, including exercise and inspiratory muscle training, on their quality of life. This multi-center, randomized controlled trial will compare these rehabilitation efforts to usual care, aiming to understand their impact on patient well-being and health outcomes over a six-week period. Participants will be randomly assigned to one of two groups an intervention group receiving a structured rehabilitation program with 18 sessions combining endurance, resistance, balance, mobility, and inspiratory muscle exercises conducted three times weekly over six weeks, beginning during hospital stay and continuing as outpatient care or a control group receiving usual care with bi-weekly contact from study staff. The study will also track hospital readmission and mortality rates up to six months after discharge. Throughout the study, participants will undergo baseline and week 6 assessments measuring quality of life using the Kansas City Cardiomyopathy Questionnaire and maximal inspiratory pressure as a percentage of predicted value. Additional evaluations include physical performance, frailty, pulmonary function, and monitoring of major adverse cardiovascular events. Follow-up visits will assess rehospitalization rates six months after discharge, with researchers closely monitoring participant progress and safety during the trial.

EACH-ADHF: Early Comprehensive Rehabilitation in Patients With ADHF