Actively Recruiting
Early Administration of Norepinephrine in Sepsis
Led by Tunis University · Updated on 2024-12-04
200
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The management of septic states includes, in addition to the specific treatment (antimicrobials and eradication of the source), a restoration of the hemodynamic disorders and assistance of the failing organs. In general, the restoration of hemodynamic disorders begins first with volume expansion, followed by the use of Noepinephrine (NE) when the target mean arterial pressure (MAP) is not reached after optimizing the intravascular volume. Recently, several studies have supported the interest of early NE on MAP, cardiac output and mortality. It is therefore tempting to restrict fluid administration even in the initial phase of hemodynamic management of severe sepsis by starting NE earlier.
CONDITIONS
Official Title
Early Administration of Norepinephrine in Sepsis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 or older
- Patient or legal representative has given written informed consent
- Diagnosis of sepsis according to updated sepsis 3 consensus definitions
- Mean arterial pressure less than 65 mmHg
You will not qualify if you...
- Diagnosis of septic shock prior to randomization with norepinephrine requirements exceeding trial protocol
- Pregnancy
- Need for immediate surgery
- Advanced stage cancer (neoplasia)
- Conditions requiring water restriction such as acute pulmonary edema
- Acute coronary syndrome
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
intensive care unit of the University Hospital Center La Rabta
Tunis, Tunisia, 1007
Actively Recruiting
Research Team
A
Ahlem Trifi
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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