Actively Recruiting

Phase 3
Age: 18Years +
All Genders
NCT05604638

Early Administration of Tirofiban in Patients Treated With Tenecteplase for Acute Ischemic Stroke

Led by Second Affiliated Hospital of Guangxi Medical University · Updated on 2025-12-24

348

Participants Needed

38

Research Sites

100 weeks

Total Duration

On this page

Sponsors

S

Second Affiliated Hospital of Guangxi Medical University

Lead Sponsor

G

Ganzhou City People's Hospital

Collaborating Sponsor

AI-Summary

What this Trial Is About

The purpose of this study is to assess the safety and efficacy of early administration of tirofiban in patients treated with tenecteplase for acute ischemic stroke.

CONDITIONS

Official Title

Early Administration of Tirofiban in Patients Treated With Tenecteplase for Acute Ischemic Stroke

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Received intravenous tenecteplase for acute ischemic stroke within the past 4-24 hours
  • No significant symptom change compared to baseline (increase or decrease of 0 or 1 point in NIHSS score) or mild neurological deterioration (increase of 2 points or more in NIHSS score)
  • NIHSS score of 4 or higher before randomization
  • Patient or family has signed informed consent
Not Eligible

You will not qualify if you...

  • Intracranial hemorrhage confirmed by CT or MRI after thrombolysis and before randomization
  • Occlusion in specific brain arteries shown by CTA/MRA/DSA imaging
  • Confirmed or suspected cardioembolic stroke sources including atrial fibrillation, mitral stenosis, prosthetic heart valves, endocarditis, intracardiac thrombus, dilated cardiomyopathy, or high-risk embolic sources
  • Platelet count below 100 x 10^9/L
  • Severe kidney insufficiency with glomerular filtration rate below 30 mL/min
  • Pregnant or breastfeeding women
  • Allergy to tirofiban, nickel, titanium, or related alloys
  • Neurological or psychiatric illness preventing assessment
  • Pre-existing bleeding disorders or severe heart, liver, kidney disease, or sepsis
  • Brain tumors causing space-occupying effects (except micromeningiomas)
  • Intracranial aneurysm or arteriovenous malformation
  • Life expectancy under 6 months due to advanced disease
  • Participation in other clinical trials

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 38 locations

1

Mingguang People's Hospital

Chuzhou, Anhui, China

Actively Recruiting

2

Longyan People´s Hospital, Longyan City

Longyan, Fujian, China

Actively Recruiting

3

The Second Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, China

Actively Recruiting

4

Huangmei People's Hospital

Huanggang, Hubei, China

Actively Recruiting

5

Yiling People's Hospital of Yichang city

Yichang, Hubei, China

Actively Recruiting

6

Hunan Xupu Chengnan Hospital

Huaihua, Hunan, China

Actively Recruiting

7

People's Hospital Of Shaodong

Shaoyang, Hunan, China

Actively Recruiting

8

Shaoshan People's Hospital

Xiangtan, Hunan, China

Actively Recruiting

9

Xiangtan Central Hospitall

Xiangtan, Hunan, China

Actively Recruiting

10

Hunan University of Medicine Affiliated Pingjiang Hospital

Yueyang, Hunan, China

Actively Recruiting

11

Ganzhou People's Hospital

Ganzhou, Jiangxi, China, 341000

Actively Recruiting

12

People's Hospital of Dayu County

Ganzhou, Jiangxi, China, 341000

Actively Recruiting

13

People's Hospital of Ganxian District

Ganzhou, Jiangxi, China, 341000

Actively Recruiting

14

People's Hospital of Quannan County

Ganzhou, Jiangxi, China, 341000

Actively Recruiting

15

People's Hospital of RuiJin City

Ganzhou, Jiangxi, China, 341000

Actively Recruiting

16

People's Hospital of Shangyou County

Ganzhou, Jiangxi, China, 341000

Actively Recruiting

17

People's Hospital of Xinfeng County

Ganzhou, Jiangxi, China, 341000

Actively Recruiting

18

People's Hospital of Xunwu County

Ganzhou, Jiangxi, China, 341000

Actively Recruiting

19

People's Hospital of Yudu County

Ganzhou, Jiangxi, China, 341000

Actively Recruiting

20

Ganzhou Municipal Hospital

Ganzhou, Jiangxi, China

Actively Recruiting

21

Nankang TCM Hospital

Ganzhou, Jiangxi, China

Actively Recruiting

22

People's Hospital of Anyuan County

Ganzhou, Jiangxi, China

Actively Recruiting

23

People's Hospital of Chongyi County

Ganzhou, Jiangxi, China

Actively Recruiting

24

People's Hospital of Shicheng County

Ganzhou, Jiangxi, China

Actively Recruiting

25

Second Hospital of Xingguo County

Ganzhou, Jiangxi, China

Actively Recruiting

26

Second People's Hospital of Yudu County

Ganzhou, Jiangxi, China

Actively Recruiting

27

The People's Hospital of Ningdu County

Ganzhou, Jiangxi, China

Actively Recruiting

28

Traditional Chinese Medicine Hospital of Xingguo County

Ganzhou, Jiangxi, China

Actively Recruiting

29

Traditional Chinese Medicine Hospital of Yudu County

Ganzhou, Jiangxi, China

Actively Recruiting

30

Affiliated Hospital of Jiujiang University

Jiujiang, Jiangxi, China

Actively Recruiting

31

Ji'an Central People's Hospital

Ji’an, Jiangxi, China

Actively Recruiting

32

People's Hospital of Wan'an county

Ji’an, Jiangxi, China

Actively Recruiting

33

Jiangxi Provincial People's Hospital

Nanchang, Jiangxi, China

Actively Recruiting

34

People's Hospital of Yichun

Yichun, Jiangxi, China

Actively Recruiting

35

Yingtan People's Hospital

Yingtan, Jiangxi, China

Actively Recruiting

36

Songyuan Jilin Oilfield Hospital

Songyuan, Jilin, China

Actively Recruiting

37

Dalian Municipal Central Hospital

Dalian, Liaoning, China

Actively Recruiting

38

Zhongmeng Hospital of Hexigten Banner

Chifeng, Neimenggu, China

Actively Recruiting

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Research Team

D

Deyan Kong, MD

CONTACT

G

Guoyong Zeng, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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