Actively Recruiting
Early Amiodarone in Shockable Cardiac Arrest
Led by Oregon Health and Science University · Updated on 2025-12-19
585
Participants Needed
1
Research Sites
160 weeks
Total Duration
On this page
Sponsors
O
Oregon Health and Science University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The primary objective of this pilot, pragmatic stepped-wedge cluster randomized trial is to evaluate if a modified cardiac arrest treatment algorithm calling for the administration of the initial amiodarone dose one 2-minute cycle earlier than current guidelines (during the same cycle as the initial dose of epinephrine) improves the time to amiodarone delivery in those with out-of-hospital cardiac arrest due to refractory ventricular fibrillation or ventricular tachycardia compared to usual care.
CONDITIONS
Official Title
Early Amiodarone in Shockable Cardiac Arrest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Emergency medical services (EMS)-treated non-traumatic out-of-hospital cardiac arrest
- Initial rhythm on EMS rhythm assessment of ventricular fibrillation or ventricular tachycardia
- Recurrence or persistence of ventricular fibrillation or ventricular tachycardia after one defibrillation attempt
You will not qualify if you...
- Known allergy to amiodarone
- EMS-assessed contraindication to amiodarone
- Pre-existing "do-not-attempt-resuscitation" orders
- Inter-facility transportations
- Initial care by a non-participating EMS agency able to perform advanced life support interventions
- Pediatric patient as determined by EMS
- Prisoners
- Pregnant patients
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Oregon Health & Sciences University
Portland, Oregon, United States, 97035
Actively Recruiting
Research Team
J
Joshua Lupton, MD, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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