Actively Recruiting
Early Angiotensin II in the Emergency Department
Led by Brett A Faine · Updated on 2026-03-11
20
Participants Needed
1
Research Sites
86 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This pilot study will enroll 20 patients with septic shock and require emergent vasopressor support in the emergency department (ED). The primary objective of the study is to determine the feasibility of early peripheral administration of angiotensin II for treatment of septic shock in the ED
CONDITIONS
Official Title
Early Angiotensin II in the Emergency Department
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Requiring norepinephrine at a dose of 0.05-0.25 mcg/kg/min despite adequate fluid resuscitation
- Receiving intravenous antibiotics or clinician's intention to administer antibiotics at enrollment
- Able to provide written informed consent or have a legally authorized representative provide consent
You will not qualify if you...
- Acute coronary syndrome
- Cardiogenic shock
- History of mesenteric ischemia
- History of aortic dissection or abdominal aortic aneurysm
- Expected lifespan less than 12 hours
- Hemorrhagic shock, such as actively receiving blood transfusion
- Active use of two vasoactive agents before enrollment
- Pre-existing thromboembolic disease or inability to tolerate blood clot prevention medications
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States, 52242
Actively Recruiting
Research Team
B
Brett Faine, PharmD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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