Actively Recruiting
Early Assessment of Cardiac Function After Treatment With CAR-T Cells
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-09-02
60
Participants Needed
1
Research Sites
120 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
CAR-T cells (Chimeric Antigen Receptor) are a new immunotherapy, based on the genetic modification of autologous T lymphocytes. CAR-T cell therapy is not devoid of complications. Among the most frequent complications are the risk of infection, cytokine release syndrome (CRS) and neurotoxicity. Nevertheless, some authors have reported serious acute cardiac events in a limited number of patients, often contemporaneous with CRS or sepsis, questioning the imputability of CAR-T cells in this heart disease. This study aims to estimate the incidence of a possible early cardiotoxicity associated with CAR-T cells. The main endpoint will be the change in cardiac function (LVEF: left ventricular ejection fraction) assessed by ultrasound between the pre CAR-T assessment and the early post CAR-T ultrasound (D3-D5).
CONDITIONS
Official Title
Early Assessment of Cardiac Function After Treatment With CAR-T Cells
Who Can Participate
Eligibility Criteria
You may qualify if you...
- CAR-T cells infusion received within 3 to 5 days before the echocardiography
- Pre-therapeutic cardiac assessment including echocardiography and ECG before conditioning and CAR-T infusion
- Patient agrees to participate in research
- Patient is affiliated with a social security system or beneficiary of state medical insurance help
You will not qualify if you...
- Opposition or withdrawal of consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Critical care medicine department
Paris, France, 75012
Actively Recruiting
Research Team
J
Jérémie JOFFRE, MD, PhD
CONTACT
H
Hafid AIT-OUFELLA, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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