Study of Early Breast Development and Environmental Factors in Girls Aged 6 to 8 Years Analyzing Biological and Clinical Changes and Impact of Environmental Health Measures

What this Trial Is About

Researchers are studying early breast development in girls aged 6 to 8 years, a phenomenon that has been increasing and is often without a clear medical cause. This trial aims to analyze many factors, including body fat, metabolism, exposure to endocrine disruptors, and epigenetic changes. The study also explores how environmental health measures might influence these factors and uses experimental models to test related biological hypotheses. The study involves two groups girls aged 6 to 8 years with signs of breast development who are scheduled for pediatric day hospital care, and control girls of the same age without signs of puberty undergoing routine consultations or MRI scans for other reasons. Participants will have breast, ovary, uterus sizes, and abdominal fat measured by MRI at the start and after three months. Various biological and metabolic markers will be tested through blood, urine, and hair samples, and dental photographs will assess tooth mineralization. Participants will be followed over six months with measurements of growth, body mass index, and hormone levels at regular intervals. Assessments include MRI scans, bone age X-rays, and hormone tests at baseline, three months, and six months. The study monitors changes in breast development, fat distribution, and related biological markers to understand the impact of environmental factors and health measures on early puberty progression.

Early Breast Growth in Girls Aged 6 to 8 Years in the Current Environmental Context