Actively Recruiting
Early Catheter-directed Treatment of High Risk Pulmonary Embolism
Led by Leipzig Heart Science gGmbH · Updated on 2026-03-04
210
Participants Needed
18
Research Sites
130 weeks
Total Duration
On this page
Sponsors
L
Leipzig Heart Science gGmbH
Lead Sponsor
H
Heart Center Leipzig at University of Leipzig
Collaborating Sponsor
AI-Summary
What this Trial Is About
Prospective, multicenter, open label, randomized controlled clinical trial to compare the effects of an early catheter-directed treatment plus conventional care with conventional care in patients with high-risk pulmonary embolism
CONDITIONS
Official Title
Early Catheter-directed Treatment of High Risk Pulmonary Embolism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pulmonary embolism confirmed by CT angiogram with high mortality risk as defined by ESC guidelines
- Presence of cardiac arrest or obstructive shock (systolic BP <90 mmHg or need for vasopressors to maintain BP ≥90 mmHg despite adequate filling) combined with signs of end-organ hypoperfusion (cold, clammy skin, oliguria, or serum lactate ≥2 mmol/L)
- Evidence of right-ventricular dysfunction on transthoracic echocardiogram or CT scan
- Age 18 years or older
You will not qualify if you...
- Contraindications for catheter-based treatment
- Contraindications to systemic fibrinolytic treatment or anticoagulation including:
- Active, potentially life-threatening bleeding
- Surgery within 24 hours before screening
- Cranial or spinal surgery within 14 days before screening
- Stroke within 14 days before screening
- Intracranial tumor
- Any other clinically relevant condition as judged by the treating investigator
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 18 locations
1
Universitätsklinikum Freiburg
Bad Krozingen, Germany, 79189
Actively Recruiting
2
Oberlausitzklinikum Bautzen, Medizinische Klinik I
Bautzen, Germany, 02625
Actively Recruiting
3
Universitätsklinikum Bonn
Bonn, Germany, 53127
Actively Recruiting
4
Universitätsklinik Düsseldorf, Klinik für Kardiologie, Pneumologie und Angiologie
Düsseldorf, Germany, 40225
Actively Recruiting
5
HELIOS Klinikum Erfurt
Erfurt, Germany, 99089
Actively Recruiting
6
Universitätsklinikum Frankfurt, Med. Klinik III - Kardiologie, Angiologie
Frankfurt am Main, Germany, 60590
Actively Recruiting
7
Universitätsklinikum Halle
Halle, Germany, 06120
Actively Recruiting
8
Asklepios Klinik St. Georg
Hamburg, Germany, 20099
Actively Recruiting
9
SLK-Kliniken Heilbronn
Heilbronn, Germany, 74078
Actively Recruiting
10
Westpfalz-Klinikum GmbH, Klinik für Innere Medizin 2
Kaiserslautern, Germany, 67655
Actively Recruiting
11
Universitätsklinikum Leipzig
Leipzig, Germany, 04103
Actively Recruiting
12
Heart Center Leipzig at University of Leipzig, Department of Internal Medicine/Cardiology
Leipzig, Germany, 04289
Actively Recruiting
13
Universitätsklinikum Mannheim
Mannheim, Germany, 68167
Actively Recruiting
14
Klinik für Innere Medizin 8 Schwerpunkt Kardiologie Universitätsklinik der Paracelsus Medizinischen Privatuniversität Klinikum Nürnberg I Campus Süd
Nuremberg, Germany, 90471
Actively Recruiting
15
Bundeswehrkrankenhaus Ulm, Abteilung I - Innere Medizin, Schwerpunkt Kardiologie
Ulm, Germany, 89081
Actively Recruiting
16
Schwarzwald-Baar-Klinikum
Villingen-Schwenningen, Germany, 78052
Actively Recruiting
17
Rems-Murr-Kliniken
Winnenden, Germany, 71364
Actively Recruiting
18
Helios Kliniken Wuppertal
Wuppertal, Germany, 42117
Actively Recruiting
Research Team
K
Karl Fengler, MD, Assoc. Prof.
CONTACT
H
Holger Thiele, MD, Prof. Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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