Study of Early Stopping Sedation and Temperature Treatment in Adults With a Favorable EEG After Cardiac Arrest

What this Trial Is About

Researchers are evaluating the feasibility and safety of early weaning from intensive care treatment in adult patients who have experienced cardiac arrest and show a favorable EEG pattern within the first 12 hours. This favorable EEG indicates no or mild brain injury after the arrest. The study aims to determine if early stopping of sedation and targeted temperature management TTM benefits this subgroup compared to standard care. The study uses a cluster randomized crossover design with two groups. One group receives early cessation of sedation and TTM, followed by weaning from mechanical ventilation if appropriate. The other group receives standard care with sedation and TTM continued for at least 24 to 48 hours. The study will include about forty patients admitted to the ICU with postanoxic encephalopathy and an early favorable EEG. Participants will be monitored during their ICU stay, with researchers measuring the total time on mechanical ventilation, length of ICU stay, sedation duration, and any need to restart sedation or re-intubate. Neurological outcomes, cognitive function, complications, serious adverse events, and mortality will be assessed up to six months after the cardiac arrest. The entire ICU admission period, up to 30 days, will be observed for these outcomes to evaluate safety and feasibility.

Early Cessation of Sedation and TTM in Patients With a Favourable EEG After Cardiac Arrest