Actively Recruiting
Early Cessation of Sedation and TTM in Patients With a Favourable EEG After Cardiac Arrest
Led by Medisch Spectrum Twente · Updated on 2024-05-13
40
Participants Needed
2
Research Sites
133 weeks
Total Duration
On this page
Sponsors
M
Medisch Spectrum Twente
Lead Sponsor
R
Rijnstate Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this study is to estimate the feasibility and safety of early weaning from ICU treatment in patients after cardiac arrest and an early (\< 12 h) favourable EEG pattern (indicating no or mild postanoxic encephalopathy).
CONDITIONS
Official Title
Early Cessation of Sedation and TTM in Patients With a Favourable EEG After Cardiac Arrest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients after cardiac arrest admitted to the ICU for treatment with sedation, TTM and mechanical ventilation.
- Age 18 years or older.
- Continuous EEG measurement started within 12 hours after cardiac arrest.
- Favourable EEG pattern within 12 hours after arrest, defined as a continuous background pattern (NVN, 2019; Ruijter et al., 2019).
- Possibility to stop sedative treatment within three hours after identification of a favourable EEG pattern.
- Written informed consent (deferred).
You will not qualify if you...
- A known history of another medical condition with limited life expectancy (<6 months).
- Any progressive brain illness, such as a brain tumour or neurodegenerative disease.
- Pre-admission Glasgow Outcome Scale Extended score of 4 or lower.
- Reason other than neurological condition to continue sedation and/or ventilation.
- Follow-up impossible due to logistic reasons.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Rijnstate hospital
Arnhem, Gelderland, Netherlands, 6815AD
Actively Recruiting
2
Medisch Spectrum Twente
Enschede, Overijssel, Netherlands, 7500KA
Actively Recruiting
Research Team
M
Marleen C. Tjepkema-Cloostermans, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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