Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06411431

Early Chest Tube Removal After Surgery for Primary Spontaneous Pneumothorax: A Randomized Controlled Trial

Led by Swedish Medical Center · Updated on 2025-05-16

200

Participants Needed

1

Research Sites

217 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Video-assisted thoracoscopic surgery (VATS) with blebectomy/wedge resection plus pleurodesis is the standard of care for recurrent primary spontaneous pneumothorax (PSP) or, in certain instances, after the first episode. The chest tube from surgery is typically kept to suction until post-operative day (POD) 2 to allow for scarring of the lung to the chest to prevent recurrence. However, the scarring process takes place over a period of weeks and is there no data to support POD#2 as the best time to remove the chest tube. Also, shorter chest tube duration can lower length of stay, patient discomfort, and hospital cost. The goal of this randomized study is to determine if early removal (POD#1) of chest tube after video-assisted thoracoscopic surgery (VATS) with blebectomy/wedge resection plus chemical pleurodesis for primary spontaneous pneumothorax (PSP): * has no worse 2-year recurrence rate compared to standard removal (POD#2) * will lower length of stay compared to standard removal * will result in less complications or re-interventions compared to standard removal Participants will be asked to join prior to surgery. Following standard-of-care surgery, participants will be screened for randomization. If still eligible, participants will be randomized for early chest tube removal or standard removal. Early Removal will happen within 24 hours after surgery, with Standard Removal happening day 2 after surgery. Participants will follow-up with the study team for 2 years on the following schedule: * In clinic with a chest x-ray 2 weeks after surgery * By phone 3 months after surgery * In clinic with a chest x-ray 1 year after surgery * In clinic with a chest x-ray 2 years after surgery

CONDITIONS

Official Title

Early Chest Tube Removal After Surgery for Primary Spontaneous Pneumothorax: A Randomized Controlled Trial

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient undergoing video assisted thoracoscopic surgery with blebectomy/wedge resection and chemical pleurodesis for primary spontaneous pneumothorax
  • Adult patients (> 18 years)
Not Eligible

You will not qualify if you...

  • History of chest radiation or prior ipsilateral chest surgery
  • Tuberculosis or other infectious lung diseases
  • Secondary spontaneous pneumothorax due to conditions like COPD, cancer, cystic fibrosis, connective tissue disease, sarcoidosis, or catamenial pneumothorax
  • Pneumothorax caused by trauma
  • Presence of hemothorax or hydropneumothorax
  • Immunocompromised status including neutropenia, leukopenia, or use of immunosuppressive medications such as chemotherapy, transplant drugs, or steroids (≥5 mg prednisone or equivalent)
  • Interstitial lung disease
  • Children under 18 years old
  • Pregnant women
  • Adults unable to provide informed consent
  • Prisoners

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Swedish Cancer Institute

Seattle, Washington, United States, 98104

Actively Recruiting

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Research Team

B

Brian Louie, M.D.

CONTACT

J

John Campbell, M.D.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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