Actively Recruiting
Early Childhood Obesity Programming by Intrauterine Growth Restriction
Led by Montefiore Medical Center · Updated on 2025-09-15
400
Participants Needed
1
Research Sites
495 weeks
Total Duration
On this page
Sponsors
M
Montefiore Medical Center
Lead Sponsor
E
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. Here, the investigators address major questions about early childhood obesity programming by studying CD3+ T-cells from intrauterine growth restricted (IUGR) newborns who have an increased risk for obesity and other metabolic disorders in adult life.
CONDITIONS
Official Title
Early Childhood Obesity Programming by Intrauterine Growth Restriction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy singleton term intrauterine growth restricted (IUGR) infants with birth weight below the 10th percentile for gestational age and gender based on WHO growth curves
- Healthy singleton term appropriate for gestational age (AGA) infants with birth weight between the 10th and 90th percentile
- Mothers of reproductive age, healthy enough to achieve pregnancy
- Delivery of a single healthy live term infant at 37 weeks' gestational age or later
- Written informed consent given in accordance with institutional and federal guidelines
You will not qualify if you...
- Multiple gestation pregnancies
- Maternal depression
- Maternal renal disease
- History of maternal smoking during the second and third trimesters of pregnancy
- Maternal gestational diabetes or type 2 diabetes
- Preterm birth before 37 weeks' gestation
- Known chromosomal or congenital anomalies in the infant
- Infants in extremis
- Low Apgar scores (below 7 at 5 minutes of age)
- Known congenital bacterial or non-bacterial infections
- Known inborn errors of metabolism
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Jack D. Weiler Hospital
The Bronx, New York, United States, 10461
Actively Recruiting
Research Team
S
Sandra Reznik, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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