Actively Recruiting
Early vs Delayed Surgery for Stricturing CD--a RCT
Led by Zhu Weiming · Updated on 2026-04-13
138
Participants Needed
1
Research Sites
416 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The management of stricturing Crohn's disease (CD) remains challenging. Although surgical resection may be the final way to solve it, the efficacy of biologics for symptomatic CD associated strictures was acceptable. In clinical practice, the chioce of treatment is particularly difficult. Therefore, a clinical trial of biologics versus surgery is needed to assess which one is prefered.
CONDITIONS
Official Title
Early vs Delayed Surgery for Stricturing CD--a RCT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 60 years
- Presence of intestinal obstructive symptoms
- Confirmed intestinal strictures
- Failure of traditional drugs to induce remission
- Evidence of active bowel inflammation
- Not suitable for endoscopic balloon dilation
- Signed written informed consent given by participant
You will not qualify if you...
- Unsuccessful medical treatment of intestinal obstruction
- Complete intestinal obstruction
- Contraindication for biologic treatments
- Presence of penetrating disease
- Short small bowel
- Suspicion of bowel tumor
- No confirmed intestinal strictures
- Severe disease affecting other organ systems
- Obstructive symptoms despite use of over two types of biologics
- Successful treatment with traditional drugs
- Participation in other clinical research studies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of General Surgery, Jinling hosptal,Medical School of Nanjing University
Nanjing, Jiangsu, China, 210002
Actively Recruiting
Research Team
W
Weinming Zhu, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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