Actively Recruiting
Early Detection of CTEPH in Patients After APE
Led by Institute of Health Information and Statistics of the Czech Republic · Updated on 2025-11-21
500
Participants Needed
10
Research Sites
90 weeks
Total Duration
On this page
Sponsors
I
Institute of Health Information and Statistics of the Czech Republic
Lead Sponsor
G
General University Hospital, Prague
Collaborating Sponsor
AI-Summary
What this Trial Is About
The project is a national, prospective, multicenter, observational pilot project of screening CTEPH in pacients after APE in the Czech Republic. The main goal of the project is to methodically prepare, implement and evaluate a pilot project that will verify the suitability of the proposed procedure of early detection of Chronic tromboembolic pulmonary hypertesion in such a way as to ensure the maximum positive impact on the health of the population and high cost-effectiveness of the whole process.
CONDITIONS
Official Title
Early Detection of CTEPH in Patients After APE
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- Signed consent to participate in the project and GDPR
- Patients with an episode of acute pulmonary embolism in the last 3-12 months, with ongoing anticoagulation therapy
- Patients with new-onset and ongoing or progressive dyspnea (minimum NYHA II) after a pulmonary embolism episode or worsening of dyspnea by at least 1 NYHA grade compared to before the episode
- Asymptomatic patients after pulmonary embolism with at least one risk factor including:
- Echocardiographic evidence of severe pulmonary hypertension at PE diagnosis (PASP >60 mmHg)
- Antiphospholipid syndrome with triple positivity
- Infected permanent venous inlets and cardiac pacing/defibrillation intravascular systems
- Presence of ventriculoatrial shunt for hydrocephalus treatment
- Nonspecific intestinal inflammation (ulcerative colitis, Crohn's disease)
- History of splenectomy
- Myeloproliferative disorders
- Chronic osteomyelitis
You will not qualify if you...
- Not agreeing to participate in the project
- Contraindications to treatment
AI-Screening
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Trial Site Locations
Total: 10 locations
1
Brno University Hospital
Brno, Czechia
Actively Recruiting
2
Havlíčkův Brod Hospital
Havlíčkův Brod, Czechia
Actively Recruiting
3
University Hospital Hradec Králové
Hradec Králové, Czechia
Actively Recruiting
4
Jihlava Hospital
Jihlava, Czechia
Actively Recruiting
5
Náchod Hospital
Náchod, Czechia
Actively Recruiting
6
University Hospital Olomouc
Olomouc, Czechia
Actively Recruiting
7
University Hospital Ostrava
Ostrava, Czechia
Actively Recruiting
8
Pardubice Hospital
Pardubice, Czechia
Actively Recruiting
9
Rychnov nad Kněžnou Hospital
Rychnov nad Kněžnou, Czechia
Actively Recruiting
10
Tábor Hospital
Tábor, Czechia
Actively Recruiting
Research Team
K
Kateřina Ondrášková, Msc
CONTACT
L
Lucie Mandelová, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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