Actively Recruiting
Early Diagnosis of Pancreatic Cancer Duodenal Fluid-Based Biomarker Exploratory Study
Led by Do Hyun Park · Updated on 2025-06-22
263
Participants Needed
3
Research Sites
156 weeks
Total Duration
On this page
Sponsors
D
Do Hyun Park
Lead Sponsor
T
The Cleveland Clinic
Collaborating Sponsor
AI-Summary
What this Trial Is About
Purpose Pancreatic cancer is the fourth leading cancer-related mortality disease in the United States, with a five-year survival rate of 11%, and only 10 15% of all pancreatic cancer patients are operable or borderline operable. Therefore, there is an unmet need for early diagnosis of pancreatic cancer; however, biomarkers related to this are not well understood. This study aims to identify biomarkers for the early diagnosis of pancreatic cancer through duodenal pancreatic juice, which can be easily obtained through an endoscopy.
CONDITIONS
Official Title
Early Diagnosis of Pancreatic Cancer Duodenal Fluid-Based Biomarker Exploratory Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be at least 19 years old.
- Undergo medically planned upper endoscopy, endoscopic ultrasound, or ERCP.
- For pancreatic cancer group: have biopsy-proven stage I-IV pancreatic ductal adenocarcinoma or suspected pancreatic cancer on imaging with scheduled endoscopic ultrasound-guided biopsy.
- For non-pancreatic cancer group: have pancreatic cystic tumors, acute or chronic pancreatitis, or no evidence of pancreatic disease.
- Complete informed consent for the planned endoscopic procedure before duodenal fluid collection.
You will not qualify if you...
- Have anatomy that prevents direct duodenal fluid sampling.
- Be hemodynamically unstable and unable to undergo endoscopy.
- Have uncontrolled large amounts of ascites fluid preventing endoscopy.
- Have an uncorrected coagulation disorder preventing endoscopy.
AI-Screening
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Trial Site Locations
Total: 3 locations
1
University of Colorado Hospital
Aurora, Colorado, United States, 80045
Actively Recruiting
2
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
3
Asan Medical Center
Seoul, South Korea, 05505
Actively Recruiting
Research Team
H
HyeJin Song, CRC
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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