Non-Invasive Breath, Saliva, and Urine Testing for Early Detection of Upper Digestive Tract Disease in Adults Aged 18 to 90

What this Trial Is About

Upper digestive tract cancer UDC includes cancers from the oral cavity to the duodenum and is a significant health challenge worldwide. Most patients are diagnosed at a late stage, leading to poor survival rates below 20%. Researchers are studying a non-invasive breath test using mass spectrometry to detect volatile organic compounds VOCs that may help identify UDC earlier. This approach also includes analyzing saliva and urine samples to improve early diagnosis and potentially improve outcomes. The study collects non-invasive samples such as breath, saliva, and urine from patients with upper digestive tract cancer as well as from those without the disease. Participants are patients undergoing routine clinical care involving endoscopy, surgical resection, or treatment of orodigestive tract disease. The goal is to identify unique VOC patterns in these samples that could serve as biomarkers for early cancer detection. Participants will provide breath, saliva, and urine samples during their clinical visits. Researchers will analyze these samples using mass spectrometry over a period of up to five years to evaluate the effectiveness of the non-invasive testing. This study aims to demonstrate the feasibility of this testing method and support its future use in medical practice, potentially enabling earlier detection and treatment of upper digestive tract cancers.

Early Diagnosis of Upper Digestive Tract Disease