Actively Recruiting
Early Diagnosis of Upper Digestive Tract Disease Using Non-Invasive Breath, Saliva, and Urine Testing
Led by Imperial College London · Updated on 2025-02-10
180
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Upper digestive tract cancer (UDC) includes cancers from the oral cavity to the duodenum and is a significant health challenge worldwide. Most patients are diagnosed at a late stage, leading to poor survival rates below 20%. Researchers are studying a non-invasive breath test using mass spectrometry to detect volatile organic compounds (VOCs) that may help identify UDC earlier. This approach also includes analyzing saliva and urine samples to improve early diagnosis and potentially improve outcomes. The study collects non-invasive samples such as breath, saliva, and urine from patients with upper digestive tract cancer as well as from those without the disease. Participants are patients undergoing routine clinical care involving endoscopy, surgical resection, or treatment of orodigestive tract disease. The goal is to identify unique VOC patterns in these samples that could serve as biomarkers for early cancer detection. Participants will provide breath, saliva, and urine samples during their clinical visits. Researchers will analyze these samples using mass spectrometry over a period of up to five years to evaluate the effectiveness of the non-invasive testing. This study aims to demonstrate the feasibility of this testing method and support its future use in medical practice, potentially enabling earlier detection and treatment of upper digestive tract cancers.
CONDITIONS
Brief Title
Early Diagnosis of Upper Digestive Tract Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient is 18 years or older and younger than 90 years of age
- Patient is undergoing endoscopy as part of routine clinical care, OR
- Patient is undergoing surgical resection of orodigestive tract disease as part of routine clinical care, OR
- Patient is undergoing treatment of orodigestive tract disease as part of routine clinical care
You will not qualify if you...
- Patient lacks capacity or is unable to provide informed consent
- Patient is younger than 18 years or 90 years or older
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 5 years
Participants who undergo routine care are observed using non-invasive breath, saliva, and urine testing over time.
Periodic assessments during routine clinical care
Trial Site Locations
Total: 1 location
1
Imperial College London
London, United Kingdom, W2 1NY
Actively Recruiting
Research Team
Y
Yan Mei Goh, MBChB, MRCS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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