Actively Recruiting
Early Discontinuation of Steroid Treatment in Negative FDG-PET/CT Patients With Idiopathic Retroperitoneal Fibrosis
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-05-25
41
Participants Needed
15
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Adult patients with a diagnosis of idiopathic retroperitoneal fibrosis Prospective multicentric cohort study Intervention : administration of prednisone during 9 to 21 months at 1mg/kg/day at inclusion.
CONDITIONS
Official Title
Early Discontinuation of Steroid Treatment in Negative FDG-PET/CT Patients With Idiopathic Retroperitoneal Fibrosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient over 18 years old
- New onset or untreated relapsing of active idiopathic retroperitoneal fibrosis (IRF) defined by related disease symptoms or elevated CRP level (>20 mg/l)
- Retroperitoneal peri-aortic mass surrounding abdominal vessels visible on CT scan
You will not qualify if you...
- Secondary retroperitoneal fibrosis including drug-related fibrosis, active infections (e.g., tuberculosis), malignancies, systemic vasculitis, or Erdheim-Chester disease
- Contraindication to FDG-PET/CT or CT scan with contrast
- Contraindication to prednisone treatment
- Active infection
- Severe acute or chronic liver disease
- Active or history of malignancy within last 5 years (except treated skin or cervical carcinoma in situ)
- Serum creatinine level >400 µmol/L unrelated to IRF
- Live vaccination within 4 weeks before inclusion
- Use of inhaled glucocorticoids except for documented asthma
- Use of rituximab, methotrexate, alemtuzumab, cyclophosphamide, azathioprine, mycophenolate mofetil, infliximab, adalimumab, or etanercept within past 3 months
- Pregnancy or breastfeeding
- Lack of social security affiliation
- Legal protective measures or deprivation of freedom
- Refusal to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 15 locations
1
Médecine Interne
Agen, France, France, 47000
Actively Recruiting
2
Médecine interne
Brest, France, France, 29200
Actively Recruiting
3
Médecine interne et maladies infectieuses - GH Sud Haut Lévêque
Bordeaux, France, 33604
Actively Recruiting
4
Médecine interne - Ambroise Paré
Boulogne-Billancourt, France, 92100
Actively Recruiting
5
Médecine interne - Henri-Mondor
Créteil, France, 94000
Actively Recruiting
6
Médecine interne et immunologie clinique - Dijon
Dijon, France, 21000
Actively Recruiting
7
Médecine interne - Lille
Lille, France, 59000
Active, Not Recruiting
8
Médecine Interne - La Timone
Marseille, France, 13005
Actively Recruiting
9
Médecine interne - Saint Antoine
Paris, France, 75012
Actively Recruiting
10
Médecine Interne, Vascularites et Myosites - La Pitié Salpêtrière
Paris, France, 75013
Actively Recruiting
11
Médecine interne - Cochin
Paris, France, 75014
Actively Recruiting
12
Médecine vasculaire - HEGP
Paris, France, 75015
Actively Recruiting
13
Médecine Interne - Bichat
Paris, France, 75018
Actively Recruiting
14
Néphrologie - Bichat
Paris, France, 75018
Active, Not Recruiting
15
Médecine interne - Delafontaine
Saint-Denis, France, 93200
Active, Not Recruiting
Research Team
K
Karim SACRE
CONTACT
K
Khadija BENALI
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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