Actively Recruiting
Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke
Led by Unidade Local de Saúde de Coimbra, EPE · Updated on 2026-01-29
1300
Participants Needed
3
Research Sites
130 weeks
Total Duration
On this page
Sponsors
U
Unidade Local de Saúde de Coimbra, EPE
Lead Sponsor
U
Unidade Local de Saúde São João
Collaborating Sponsor
AI-Summary
What this Trial Is About
Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also carries potential risks, such as neurological deterioration in the presence of hemodynamic instability. In this study, the primary aim is to investigate whether early mobilization, guided by hemodynamic evaluation after acute ischemic stroke offers superior outcomes compared to standard clinical care.
CONDITIONS
Official Title
Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with ischemic stroke aged 18 years or older
- Ability to undergo carotid and transcranial Doppler ultrasound
- Ability to mobilize within 48 hours
- Informed consent obtained from the patient or legal representative
You will not qualify if you...
- Pre-existing disability with modified Rankin Scale score 4 or higher
- Diagnosis of Transient Ischemic Attack (TIA)
- Severe hemodynamic instability, including systolic blood pressure below 100 mmHg or above 220 mmHg
- Peripheral oxygen saturation below 92%
- Heart rate below 40 or above 112 beats per minute
- Body temperature above 38.5°C
- Neurological deterioration with altered consciousness (Glasgow Coma Scale below 10)
- Neurosurgical intervention within the past 30 days
- Rapidly progressive fatal disease (e.g., terminal cancer)
- Need for continuous monitoring or intravenous drug infusion
- Acute deep vein thrombosis or pulmonary embolism
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
Unidade Local de Saude de Coimbra
Coimbra, Coimbra District, Portugal, 3004-561
Actively Recruiting
2
Unidade Local de Saúde de Santa Maria
Lisbon, Lisbon District, Portugal, 1649-028
Not Yet Recruiting
3
Unidade Local de Saúde de São João
Porto, Porto District, Portugal, 4200-319
Not Yet Recruiting
Research Team
J
Joao Sargento Freitas, MD, PhD
CONTACT
C
Clinical Trials Unit - Coimbra Academic Clinical Center CTU-CACC Unidade Local de Saude de Coimbra
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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