Actively Recruiting
Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest
Led by Gabriel Riva · Updated on 2026-02-17
916
Participants Needed
14
Research Sites
220 weeks
Total Duration
On this page
Sponsors
G
Gabriel Riva
Lead Sponsor
S
Swedish Heart Lung Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)/ventricular tachycardia (VT) do not respond to initial defibrillation. The survival decreases with number of defibrillations required to terminate VF/VT. In 2022, one prospective cluster randomized trial showed increased survival among (OHCA) patients in refractory VF using Double Sequential Defibrillation (DSD). If DSD can increase survival among all patients in VF that dont respond to one defibrillation, i.e. before it has become refractory is not known. The aim of this trial is to assess survival with a double defibrillation strategy initiated as soon as possible among patients with Out of Hospital Cardiac Arrest with initial shockable rhythm and at least one failed standard defibrillation, compared with continued resuscitation using standard defibrillation.
CONDITIONS
Official Title
Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients with out-of-hospital cardiac arrest (OHCA) presenting with ventricular fibrillation (VF) or ventricular tachycardia (VT) at first rhythm analysis
- At least one defibrillation performed with standard anterior-lateral (A-L) electrode placement without return of spontaneous circulation (ROSC)
You will not qualify if you...
- Age under 18 years
- Obvious pregnancy
- Known preexisting Do Not Attempt Resuscitation (DNAR) order
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 14 locations
1
ARREST (AmsteRdam REsuscitation STudies)
Amsterdam, Netherlands
Not Yet Recruiting
2
Centro de Emergencias 061 Andalucía
Málaga, Andalusia, Spain, 29560
Not Yet Recruiting
3
Médico Emergencias Osakidetza EMERGENTZIAK
Bilbao, Baque Country, Spain, 48004
Not Yet Recruiting
4
Sistema de Emergencias Medicas de Catalunya
Barcelona, Catalonia, Spain, 08908
Not Yet Recruiting
5
SUMMA 112 Emergency medical services
Madrid, Madrid, Spain, 28045
Not Yet Recruiting
6
Ambulanssjukvården, Region Halland
Halmstad, Halland County, Sweden
Actively Recruiting
7
Ambulanssjukvården Region Värmland
Karlstad, Värmland County, Sweden, 65230
Actively Recruiting
8
Ambulanshelikoptern (HEMS) Västra Götalandsregionen
Kungälv, Västra Götaland County, Sweden, 442 83
Actively Recruiting
9
Sjukvården i väster
Alingsås, Sweden
Actively Recruiting
10
Emergency medical services, Södra Älvsborgs Sjukhus, Region Västra Götaland
Borås, Sweden, 501 82
Actively Recruiting
11
Prehospital Intensive Care Unit (PIV) AnOPIVA Östra Sjukhuset/SU
Gothenburg, Sweden
Actively Recruiting
12
Shalgrenska University Hospital
Gothenburg, Sweden
Actively Recruiting
13
Ambulanssjukvården Skaraborgs Sjukhus, Västra Götalandsregionen (SKAS)
Skövde, Sweden
Actively Recruiting
14
Emergency medical services NU-Sjukvården, Region Västra Götaland
Trollhättan, Sweden, 461 85
Actively Recruiting
Research Team
G
Gabriel Riva, M.D. Ph.D
CONTACT
A
Akil Awad, M.D. Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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