Actively Recruiting
Early Endovascular Treatment in Isolated Internal Carotid Artery Occlusion
Led by Sir Run Run Shaw Hospital · Updated on 2025-06-12
140
Participants Needed
1
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary hypothesis being tested in this trial is that acute ischemic stroke with isolated internal carotid artery occlusion will have improved clinical outcomes when given early endovascular treatment compared with that of given best medical treatment.
CONDITIONS
Official Title
Early Endovascular Treatment in Isolated Internal Carotid Artery Occlusion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 or older
- Signs consistent with acute ischemic stroke and randomization within 23 hours of last known well time
- Imaging within 1 hour before randomization showing isolated internal carotid artery occlusion (segments C1-C6) without ipsilateral intracranial branch occlusion
- Neurological deficit with NIHSS >5, or NIHSS ≤5 with disabling symptoms such as complete hemianopsia, severe aphasia, neglect, limb weakness preventing resistance to gravity, or clinically disabling functional loss
- Target mismatch profile on CT perfusion or MRI (ischemic core volume < 70 ml, mismatch ratio ≥1.8, and mismatch volume ≥15 ml) or clinical-imaging mismatch with ASPECTS score above 5 if perfusion data unavailable
- Modified Rankin Scale score before stroke ≤2
- Signed informed consent by patient or legally authorized representative
You will not qualify if you...
- Carotid endarterectomy within the past month
- Severe comorbid condition with life expectancy under 6 months
- Other cerebrovascular diseases like vasculitis, untreated malformations, or intracranial aneurysm
- Women who are pregnant, planning pregnancy, or breastfeeding at study time
- Known life-threatening allergic reactions to contrast or intravascular products
- Chronic internal carotid artery occlusion diagnosed or suspected more than 30 days before randomization
- Tandem occlusion involving internal carotid artery and large intracranial vessels
- No known vascular access
- Suspected aortic dissection
- Evidence of intracranial hemorrhage on imaging
- Inability or unavailability for follow-up
- Pre-existing neurological or psychiatric conditions affecting evaluations
- Seizures at stroke onset preventing accurate NIHSS assessment
- Contraindications to heparin or antiplatelet drugs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sir Run Run Shaw Hospital
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here