Comparing Phase Sensitive Inversion Recovery MRI to Conventional MRI for Early Brain Lesion Detection in Multiple Sclerosis Patients Aged 15 to 65

What this Trial Is About

Researchers are evaluating the ability of Phase-Sensitive Inversion Recovery PSIR MRI compared to conventional T2-weighted T2W and Fluid Attenuated Inversion Recovery FLAIR MRI scans to detect early brain lesions in people with Multiple Sclerosis MS. The study aims to determine if PSIR MRI can better identify different types of cortical lesions in MS patients aged 15 to 65 years. It also examines how these lesions relate to clinical disability and cognitive performance scores. This observational, cross-sectional study involves patients diagnosed with MS based on the 2017 McDonald criteria. Each participant will undergo MRI scans using PSIR, T2W, and FLAIR sequences for comparison. Two independent neuroradiologists will review the images to count and classify lesions in various brain regions. The study will measure how many lesions each MRI type detects and their clinical relevance. Participants will provide consent and undergo medical history, physical and neurological exams, and assessment with disability and cognitive tests. MRI scans will be performed with a 1.5T machine, and images will be analyzed for lesion count and location. The main outcome is the number and classification of cortical lesions over 18 months. Researchers will also monitor correlations with disability and cognition scores to assess the usefulness of PSIR imaging for MS monitoring and diagnosis.

Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI