Actively Recruiting
Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI
Led by Benha University · Updated on 2025-05-18
30
Participants Needed
3
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to compare the diagnostic accuracy of Phase-Sensitive Inversion Recovery (PSIR) MRI versus conventional T2-weighted (T2W) and Fluid Attenuated Inversion Recovery (FLAIR) sequences in detecting early brain lesions in patients with Multiple Sclerosis (MS). The study will include male and female participants aged 15-65 years diagnosed with MS per the 2017 McDonald criteria. This study hypothesizes that: * PSIR MRI will detect a significantly higher number of cortical lesions (intracortical, leukocortical, and juxtacortical) compared to conventional T2W and FLAIR sequences in MS patients (p \< 0.05). * Lesions identified exclusively by PSIR will correlate more strongly with clinical measures (EDSS disability scores and SDMT cognitive performance) than those detected by T2W/FLAIR alone, suggesting PSIR's superior sensitivity to clinically relevant pathology.
CONDITIONS
Official Title
Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 15-65 years.
- Both sexes.
- Patients diagnosed with Multiple Sclerosis according to the McDonald criteria.
You will not qualify if you...
- Age less than 15 years.
- History of stroke or previous intracranial hemorrhage.
- Contraindications to MRI scans.
- Presence of diseases that mimic Multiple Sclerosis.
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Banha University Hospitals
Banhā, Qalyubia Governorate, Egypt
Actively Recruiting
2
El Mounira Multiple Sclerosis Unit
Cairo, Egypt
Actively Recruiting
3
Naser Institute MS Unit
Cairo, Egypt
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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