Actively Recruiting
The Early and Late Contribution of Fasting and Postprandial Triglycerides on Newborn Subcutaneous and Intrahepatic Fat in Pregnancy
Led by University of Colorado, Denver · Updated on 2026-05-12
140
Participants Needed
1
Research Sites
278 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study plans to learn more about how triglyceride levels in pregnancy affect newborn fat mass. Obesity in pregnancy, in the absence of gestational diabetes, is now the most common cause of large-for-gestational-age infants and increased newborn fat mass. Previous data supports the idea that maternal triglycerides, not glucose, are the strongest predictor of both total newborn fat mass and liver fat. In this study, mothers will monitor triglyceride and glucose levels at specific points in pregnancy using point-of-care meters at home. Two weeks after birth, infants will have total fat measured by air-displacement plethysmography (PEAPOD) and liver fat measures by Magnetic Resonance Spectroscopy (MRS). The central hypothesis is that in obesity, fasting triglycerides and postprandial triglycerides will predict newborn fat mass in a free-living environment.
CONDITIONS
Official Title
The Early and Late Contribution of Fasting and Postprandial Triglycerides on Newborn Subcutaneous and Intrahepatic Fat in Pregnancy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant women less than 16 weeks gestational age
- Between the ages of 21-39 years
- Pre-pregnancy BMI 28-39 kg/m2
You will not qualify if you...
- Pre-gestational diabetes or prediabetes
- History of gestational diabetes
- History of pre-eclampsia, spontaneous pre-term delivery, or gestational hypertension less than 34 weeks
- Tobacco or illicit substance use
- Chronic steroid use
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Colorado/Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
E
Emily Z Dunn, MS, RDN
CONTACT
N
Nicole Hirsch, MS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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