Actively Recruiting

Phase 2
Phase 3
Age: 18Years +
All Genders
NCT07264543

Early Methylene Blue in the Microhemodynamics of Septic Patients

Led by Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva · Updated on 2026-03-27

50

Participants Needed

1

Research Sites

50 weeks

Total Duration

On this page

Sponsors

C

Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva

Lead Sponsor

I

Irmandade da Santa Casa de Misericordia de Curitiba

Collaborating Sponsor

AI-Summary

What this Trial Is About

The aim of the study is to evaluate the viability and feasibility of its protocol in order to conduct a larger clinical trial to assess whether methylene blue can improve patient-centered clinical outcomes such as mortality or length of hospital stay in septic shock patients.

CONDITIONS

Official Title

Early Methylene Blue in the Microhemodynamics of Septic Patients

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adult patients diagnosed with sepsis and ongoing hemodynamic dysfunction after fluid resuscitation
  • Requiring increased noradrenaline dose to keep mean arterial pressure 65 mmHg
  • Prolonged capillary refill time or septic shock by Sepsis-3 definition
  • Diagnosis confirmed within less than 6 hours before enrollment
Not Eligible

You will not qualify if you...

  • Pregnant or breastfeeding patients
  • Patients with decisions to withdraw or withhold life-sustaining treatment
  • Patients immediately after cardiac surgery
  • Patients with septic shock unlikely to survive 24 hours
  • Personal or family history of glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • Allergy to methylene blue, phenothiazines, or food dyes
  • Use of linezolid within the past 14 days
  • Use of serotonergic psychiatric medications within the past 2 weeks (except fluoxetine within 5 weeks)
  • Use of monoamine oxidase inhibitors (MAOIs) within the past 2 weeks such as rasagiline or selegiline

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

Irmandade da Santa Casa de Misericórdia de Curitiba

Curitiba, Paraná, Brazil, 80010-030

Actively Recruiting

Loading map...

Research Team

B

Bruna Dal Vesco

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here