Early Brain Stimulation to Improve Thinking and Recovery After Moderate to Severe Traumatic Brain Injury A 6-Month Study of Anodal Transcranial Electrical Stimulation Effects on Cognitive Function

What this Trial Is About

Researchers are studying how brain activity changes as people recover cognitively after moderate to severe traumatic brain injury TBI. This study also investigates how the timing of anodal transcranial electrical stimulation A-tES affects thinking skills and brain activity. The goal is to find brain patterns linked to cognitive recovery and to see whether early electrical stimulation improves cognitive function compared to stimulation given later during recovery. Participants will be randomly assigned to receive either real A-tES or sham placebo stimulation within 1 to 2 weeks after injury. All participants will perform cognitive tasks while their brain activity is recorded using EEG. They will return for follow-up visits at 3 monthswhen all receive active A-tES during tasksand at 6 months, when cognitive tests and brain recordings are done without stimulation. The study lasts 6 months and tracks cognitive performance and quality of life. Throughout the study, participants complete questionnaires, cognitive computer tasks, and EEG monitoring at each visit. Researchers measure changes in brain rhythms and task performance from enrollment through 6 months after injury. The study also compares how early versus later A-tES affects recovery. Safety and cognitive improvements are monitored during the 6-month follow-up period, helping to understand the best timing for brain stimulation therapy after TBI.

Early Neuromodulation in Traumatic Brain Injury