Early Detection of Preeclampsia in High-Risk Pregnancies Using Arterial Stiffness and Clinical Markers A Multinational Observational Study

What this Trial Is About

Preeclampsia PE remains a leading cause of maternal and fetal deaths worldwide despite advances in care. This study aims to improve early detection of PE by using a combination of new clinical tools and established diagnostic methods. It focuses on identifying the earliest signs of PE in high-risk pregnant women through advanced testing methods, which may help in better tracking and managing this condition. The study is a large multinational observational study conducted over 5 years involving participants from Canada, the US, and the UK. The study involves non-invasive measurement of arterial stiffness and wave reflection, which are combined with blood biomarkers, detailed ultrasound imaging, and physical and mental health questionnaires. Participants will have two assessment visits during pregnancy, one in the first trimester 10 to 13 weeks gestation and one in the second trimester 18 to 21 weeks gestation. At these visits, researchers will collect vascular measurements, blood samples, demographic and psychosocial information, and perform uterine artery Doppler imaging. Post-natal outcomes will be collected from medical charts 6 to 8 weeks after delivery. Participants will be involved in clinical visits during early and mid-pregnancy for comprehensive testing and questionnaires. Researchers will measure arterial stiffness alongside standard clinical markers to evaluate their role in predicting PE. The primary outcome is the diagnosis of pre-eclampsia up to 6 weeks postpartum. This detailed data collection and monitoring aim to enhance early prediction of PE and improve future preventative care strategies.

Early Prediction of Preeclampsia Using arteriaL Stiffness in High-risk prEgnancies