Study on Early Detection of Multiple Gastrointestinal Cancers Using Liquid Biopsy and Endoscopy in Adults Aged 40 to 75

What this Trial Is About

Gastrointestinal tumors such as esophageal, gastric, and colorectal cancers are common and serious in Shandong Province, China. These cancers often go undetected until they reach an advanced stage, leading to higher treatment costs and worse outcomes. Early detection through screening is important to improve cure rates and reduce deaths. This research builds on an ongoing screening program and aims to study the use of a new liquid biopsy test for early detection of multiple gastrointestinal cancers. The study will enroll 4,000 individuals aged 40 to 75 undergoing screening for the three types of gastrointestinal cancers. Participants will have simultaneous cancer screening using both the liquid biopsy test and routine endoscopic methods like gastroscopy and colonoscopy. The liquid biopsy product was developed by Nanjing Shihe Medical Laboratory and is designed to detect multiple cancers early through a blood sample. During the study, participants will provide plasma samples and undergo standard endoscopic screenings. Researchers will compare the liquid biopsy results with endoscopy findings to assess how well the blood test detects high-grade or more advanced cancers. The main outcome measured is the sensitivity of the liquid biopsy for detecting these cancers. The study runs from 2024 to 2027, with ongoing monitoring and follow-up to evaluate screening performance and safety.

Early Screening Cohort Study of Multiple Gastrointestinal Tumors