Actively Recruiting
Early Severe Illness TrAnslational BioLogy InformaticS in Humans
Led by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Updated on 2025-10-06
1000
Participants Needed
1
Research Sites
557 weeks
Total Duration
On this page
Sponsors
L
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lead Sponsor
L
London Health Sciences Centre
Collaborating Sponsor
AI-Summary
What this Trial Is About
Advanced stages of the response to life-threatening infection, severe trauma, or other physiological insults often lead to exhaustion of the homeostatic mechanisms that sustain normal blood pressure and oxygenation. These syndromic presentations often meet the diagnostic criteria of sepsis and/or the acute respiratory distress syndrome (ARDS), the two most common syndromes encountered in the intensive care unit (ICU). Although critical illness syndromes, such as sepsis and ARDS, have separate clinical definitions, they often overlap clinically and share several common injury mechanisms. Moreover, there are no specific therapies for critically ill patients, and as a consequence, approximately 1 in 4 patients admitted to the ICU will not survive. The purpose of this observational study is to identify early patient biologic factors that are present at the time of ICU admission that will help diagnose critical illness syndromes earlier, identify who could benefit most from specific therapies, and enable the discovery of new treatments for syndromes such as sepsis and ARDS.
CONDITIONS
Official Title
Early Severe Illness TrAnslational BioLogy InformaticS in Humans
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- ICU admission within 48 hours
- ICU admission occurred within 72 hours of presenting to the emergency department
- Clinical suspicion of critical illness based on at least one of the following: altered mental status (Glasgow Coma Scale less than 15), cardiovascular collapse (heart rate over 90, systolic blood pressure less than 90, use of vasopressors, or lactate over 2.0), respiratory collapse (respiratory rate over 20, low carbon dioxide levels, use of supplemental oxygen or ventilation), or suspected severe infection (fever or low temperature, abnormal white blood cell count, or use of antibiotics at ICU admission)
You will not qualify if you...
- Under 18 years of age
- More than 72 hours since ICU admission
- ICU admission more than 72 hours after presenting to the emergency department
- No evidence of critical illness (ICU admission due to bed availability rather than illness)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Aleks Leligdowicz
London, Ontario, Canada, N6A 3K7
Actively Recruiting
Research Team
A
Aleks Leligdowicz, MD PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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