Actively Recruiting
Early-stage Trial to Determine a Safe and Effective Dose for Ratutrelvir in Patients With Mild to Moderate COVID-19
Led by Traws Pharma, Inc. · Updated on 2026-01-21
90
Participants Needed
15
Research Sites
23 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an Early-stage Clinical Trial to Determine a Safe and Effective Dose for Ratutrelvir in Patients With Mild to Moderate COVID-19. It will also learn about the safety of drug Ratutrelvir. Participants will take a study drug as well as a standard therapy. A descriptive statistics will be used to present the study results.
CONDITIONS
Official Title
Early-stage Trial to Determine a Safe and Effective Dose for Ratutrelvir in Patients With Mild to Moderate COVID-19
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed SARS-CoV-2 infection for 120 h prior to randomization.
- Initial onset of signs/symptoms attributable to COVID-19 within 5 days prior to randomization.
- At least one of the symptoms attributable to COVID-19 present within 24 hours prior to the Day 1 with the severity score of 1 or higher according to the following scoring system for the assessment of severity of:
You will not qualify if you...
Medical Conditions:
-
History, current need for hospitalization or anticipated need for hospitalization for the medical treatment of COVID-19.
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Urgent or expected need for nasal high-flow oxygen therapy or positive pressure ventilation, invasive mechanical ventilation or ECMO.
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Known medical history of active liver disease .
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Receiving dialysis or history of moderate to severe renal impairment.
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Compromised immune system.
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Acute episode of chronic respiratory diseases, including bronchial asthma, chronic obstructive pulmonary disease within 30 days before screening.
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Suspected or confirmed concurrent active systemic infection..
Prior/Concomitant Therapy:
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Has received or is expected to receive any dose of a SARS-CoV-2 vaccine within 4 months of screening and during the participation in the study.
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Concomitant use of any medications or substances that are strong inducers of CYP3A4
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 15 locations
1
Novatrial
Charlestown, New South Wales, Australia, 2290
Actively Recruiting
2
Key Health
Sydney, New South Wales, Australia, 2000
Actively Recruiting
3
Momentum Clinical Research Taringa
Brisbane, Queensland, Australia, 4068
Actively Recruiting
4
Paratus Clinical(Clinical Trials Institute, Torquay)
Torquay, Victoria, Australia, 3228
Not Yet Recruiting
5
Chonnam National University Hospital
Gwangju, Donggu, South Korea, 61469
Not Yet Recruiting
6
The Catholic University of Korea, Eunpyeong St. Mary's Hospital
Seoul, Eunpyeong-gu, South Korea, 07441
Not Yet Recruiting
7
Wonju Severance Christian Hospital
Wŏnju, Gangwon-do, South Korea, 26426
Not Yet Recruiting
8
Inha University Hospital
Incheon, Jung-gu, South Korea, 22332
Not Yet Recruiting
9
Hallym University Sacred Heart Hospital Gangnam
Seoul, Seoul, South Korea, 07441
Not Yet Recruiting
10
Kaohsiung Medical University Hospital
Kaohsiung City, Kaohsiung, Taiwan, 807
Not Yet Recruiting
11
Taichung Veterans General Hospital
Taichung, Taichung, Taiwan, 407
Not Yet Recruiting
12
Taipei Medical University Hospital
Taipei, Taipei, Taiwan, 110
Not Yet Recruiting
13
Taoyuan General Hospital
Taoyuan, Taoyuan, Taiwan, 33004
Not Yet Recruiting
14
Chang Gung Memorial Hospital, Linkou Branch
Taoyuan, Taoyuan, Taiwan, 333
Not Yet Recruiting
15
Research Institute of Virology
Tashkent, Tashkent, Uzbekistan, 100194
Actively Recruiting
Research Team
E
Ekaterina Dokukina
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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