Actively Recruiting
Early Statin-Ezetimibe Combination vs. Statin Monotherapy in Stroke With Atherosclerosis
Led by Chang Gung Memorial Hospital · Updated on 2025-12-30
300
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
Sponsors
C
Chang Gung Memorial Hospital
Lead Sponsor
C
Chang Gung University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will be conducted at six medical institutions in Taiwan, recruiting patients who visit neurology outpatient clinics or are hospitalized within 30 days after an ischemic stroke. Participants will be randomly assigned to either the experimental group (moderate-intensity statin plus ezetimibe) or the control group (moderate- or high-intensity statin). Research assistants will screen patients aged 40 or older who have had an ischemic stroke or transient ischemic attack within 30 days, have atherosclerosis, and have LDL-C levels ≥100 mg/dL. Eligible cases will be reviewed by the attending physician. With physician approval, patients will be invited to join the study, and those who agree and sign informed consent will be enrolled.
CONDITIONS
Official Title
Early Statin-Ezetimibe Combination vs. Statin Monotherapy in Stroke With Atherosclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of ischemic stroke or transient ischemic attack (TIA)
- Stroke or TIA symptoms with randomization within 30 days and starting assigned medication within 2 days
- Age 20 years or older
- LDL cholesterol level 100 mg/dL or higher after the recent stroke or TIA
- Evidence of atherosclerosis
You will not qualify if you...
- End stage renal disease
- History of intolerance to statins
- History of intolerance to ezetimibe
- ALT liver enzyme level greater than 100 U/L
- Regular use of statins before the stroke
- Use of ezetimibe before the stroke
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Chang Gung Memorial Hospital, Chiayi Branch
Pozi, Taiwan, 613
Actively Recruiting
Research Team
M
Meng Lee, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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