Early Surgical Fixation of Low-Velocity Hip Fractures in Patients With Direct Oral Anticoagulation

What this Trial Is About

This research focuses on patients with intertrochanteric hip fractures who are treated with direct oral anticoagulation (DOAC) medication. It aims to compare early surgical fixation performed within 24 hours of injury to delayed surgical fixation done 48 hours or more after injury. The study evaluates whether early surgery reduces blood loss during the operation and examines how timing affects 30-day and 1-year mortality rates. A retrospective control group matched by age, gender, and fracture type is included for comparison. The study compares two groups: one undergoing early surgical fixation within 24 hours while on DOAC therapy, and a retrospective control group who had delayed surgery after 48 hours or more. Researchers assess perioperative blood loss and the need for blood transfusions within 3 days post-surgery. Coagulation parameters are also monitored during this period to understand the effects of timing on blood clotting and recovery. Participants will be monitored closely for three days after surgery to measure blood loss, transfusion needs, and coagulation status. The study collects data on patient outcomes including survival at 30 days and one year. This prospective cohort is compared to historical patient data to evaluate differences related to surgery timing. The study is sponsored by the Medical University of Vienna and follows patients from surgery through follow-up periods to gather comprehensive safety and outcome information.

Early Surgical Fixation of Low-Velocity Hip Fractures in Patients With Direct Oral Anticoagulation