Actively Recruiting
Early Use of Airway Pressure Release Ventilation (APRV) in ARDS
Led by Hospital Civil de Guadalajara · Updated on 2025-03-19
150
Participants Needed
1
Research Sites
441 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Airway pressure release ventilation (APRV) is a time-cycled, pressure controlled, intermittent mandatory ventilation mode with extreme inverse I:E ratios. Currently it is considered as a non-conventional ventilatory mode. The investigators aim to compare APRV with conventional mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS).
CONDITIONS
Official Title
Early Use of Airway Pressure Release Ventilation (APRV) in ARDS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Acute respiratory distress syndrome, according to the Berlin definition of ARDS, with adjusted pO2/FiO2 for altitude <300, and less than 48 h of endotracheal mechanical ventilation
You will not qualify if you...
- Pregnancy
- Less than 18 years-old
- Expected duration of mechanical ventilation less than 48 h
- Preexisting conditions with an expected 3-month mortality exceeding 50%
- Concurrent chemotherapy
- Confirmed intracranial hypertension
- Catastrophic cranial trauma or neuromuscular disorders that are known to prolong mechanical ventilation
- Pneumothorax at enrollment (resolved or not)
- Do-not-resuscitate order
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hospital Civil Fray Antonio Alcalde
Guadalajara, Jalisco, Mexico, 44280
Actively Recruiting
Research Team
M
Miguel Ibarra-Estrada, Dr
CONTACT
G
Guadalupe Aguirre-Avalos, Dr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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