Actively Recruiting
Early Use of Tacrolimus in HLA-Mismatched Haploidentical Allogeneic Hematopoietic Transplantation With Post-Transplant Cyclophosphamide
Led by Northside Hospital, Inc. · Updated on 2026-04-16
20
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To evalute the safety and efficacy in reducing Cytokine Release Syndrome after hematopoietic stem cell transplantation by introducing immunosuppression earlier in the transplant process
CONDITIONS
Official Title
Early Use of Tacrolimus in HLA-Mismatched Haploidentical Allogeneic Hematopoietic Transplantation With Post-Transplant Cyclophosphamide
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Availability of a 5/10-8/10 mismatched (HLA-A, B, DR) haploidentical related donor with a negative HLA cross-match in the host vs. graft direction and willing to provide peripheral blood stem cells
- Karnofsky status greater than or equal to 70%
- Hematologic malignancy requiring allogeneic transplantation
- First allogeneic transplant only; prior autologous transplant is allowed
- Age between 18 and 80 years
You will not qualify if you...
- Poor cardiac function: left ventricular ejection fraction less than 40%
- Poor pulmonary function: FEV1 and FVC less than 50% predicted
- Poor liver function: bilirubin greater than or equal to 3 mg/dL (excluding hemolysis, Gilbert's syndrome, or primary malignancy)
- Poor renal function: creatinine greater than or equal to 2 mg/dL or creatinine clearance less than 40 mL/min
- Women of childbearing potential who are currently pregnant or not using adequate contraception
- Any debilitating medical or psychiatric illness preventing informed consent or optimal treatment and follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Northside Hospital
Atlanta, Georgia, United States, 30342
Actively Recruiting
Research Team
M
Melh Solh, MD
CONTACT
C
Caitlin Guzowski, MBA, MHA, CCRC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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